TOP3B antibody (C-Term)

Catalog No. ABIN955293

The Rabbit Polyclonal anti-TOP3B antibody (ABIN955293) specifically detects TOP3B in WB and EIA. The antibody is reactive with Human and Mouse samples.

Quick Overview for TOP3B antibody (C-Term) (ABIN955293)

Target: TOP3B (Topoisomerase (DNA) III beta (TOP3B))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TOP3B antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-TOP3B Antibody

Binding Specificity: AA 825-854, C-Term

Specificity: This antibody detects TOP3B (C-term).

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse

Purification: Protein A column followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 825-854 amino acids from the C-terminal region of human TOP3B

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.

Target Details for TOP3B

Target: TOP3B (Topoisomerase (DNA) III beta (TOP3B))

Alternative Name: TOP3B

Background: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity, however, not all variants have been fully described.Synonyms: DNA topoisomerase 3-beta-1, DNA topoisomerase III beta-1, TOP3B1

Gene ID: 8940

NCBI Accession: NP_003926