Mitf produces, by alternative splicing, 10 different transcripts, all with introns, putatively encoding 10 different protein isoforms. Therefore, observed molecular weights may vary depending on MITF isoforms expressed. Users are encouraged to utilize the peptide immunogen sequence to gain further information about the isoforms recognized by the antibody.
Purification
Protein G purified
Immunogen
A synthetic peptide corresponding to amino acids 301-312 (PSTGLCSPDLVN) of itf. GenBank no. gi|1092105|prf||2022321A. The peptide immunogen sequence is 100% conserved between human, mouse, rat, pig and dog. Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Dog, Hamster, Panda, Horse, Rabbit, Pig, Platypus (100%), Bovine, Elephant, Opossum, Turkey, Xenopus (92%), Bat, Goat, Chicken (83%).