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YBX3/DBPA antibody

YBX3 Reactivity: Borrelia burgdorferi WB, LF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN964622
  • Target See all YBX3/DBPA (YBX3) products
    YBX3/DBPA (YBX3) (Y Box Binding Protein 3 (YBX3))
    Reactivity
    • 15
    • 2
    Borrelia burgdorferi
    Host
    • 17
    Rabbit
    Clonality
    • 17
    Polyclonal
    Conjugate
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This YBX3/DBPA antibody is un-conjugated
    Application
    • 17
    • 13
    • 13
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Lateral Flow (LF)
    Specificity
    This product was Protein-A purified and cross-adsorbed against MBP from monospecific antiserum by chromatography. This antibody is specific for Borrelia burgdorferi DbpA protein. A BLAST analysis was used to suggest cross-reactivity with DbpA from Borrelia burgdorferi sources based on 100% homology with the immunizing sequence. Partial reactivity is expected against Borrelia garinii sources based on 60-80% homology. Cross-reactivity with DbpA from other sources has not been determined.
    Characteristics
    This product is antibody made against DbpA, or Decorin Binding Protein A from the spirochete Borrelia burgdorferi, which is carried by Ixodes ticks. DbpA from other microbial organisms such as E. coli (ATP-dependent RNA helicase DbpA) are significantly different. The spirochete migrates from the tick midgut during tick feeding to tick salivary glands and are thus transmitted to the mammal host. This transition may be facilitated by changes in expression of some B. burgdorferi genes. Spirochetal surface adhesions mediate attachment to decorin, a major component of the host extracellular matrix, enabling bacteria to colonize in mammalian tissues. It is believed that expression of the various proteins associated with the spirochete may be regulated by the changes in tick life cycle, changes in conditions during tick feeding (such as temperature, pH, and nutrients) and/or in coordination with the course of infection of the mammal host.
    Immunogen
    MBP-fusion protein corresponding to Borrelia burgdorferi Dbp-A protein.
    Immunogen Type: RecombinantProtein
    Isotype
    IgG
  • Application Notes
    This protein-A purified antibody has been tested for use in Western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 18.5 kDa in size corresponding to Borrelia burgdorferi DbpA protein by Western blotting in the appropriate cell lysate or extract.
    Comment

    Gene Name: dbpA, BB_A24

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitution Buffer: Restore with deionized water (or equivalent), Reconstitution Volume: 100 µL
    Concentration
    1.0 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
    Expiry Date
    12 months
  • Target
    YBX3/DBPA (YBX3) (Y Box Binding Protein 3 (YBX3))
    Alternative Name
    DBP A (YBX3 Products)
    Synonyms
    CSDA antibody, CSDA1 antibody, DBPA antibody, ZONAB antibody, csda antibody, Csda antibody, Dpba antibody, MSY3 antibody, MSY4 antibody, Yb2 antibody, dbpA antibody, oxyR antibody, Dbpa antibody, Y-box binding protein 3 antibody, Y-box binding protein 3 S homeolog antibody, Y box protein 3 antibody, Y box binding protein 3 antibody, YBX3 antibody, ybx3.S antibody, Ybx3 antibody
    Background
    This product is antibody made against DbpA, or Decorin Binding Protein A from the spirochete Borrelia burgdorferi, which is carried by Ixodes ticks. DbpA from other microbial organisms such as E. coli (ATP-dependent RNA helicase DbpA) are significantly different. The spirochete migrates from the tick midgut during tick feeding to tick salivary glands and are thus transmitted to the mammal host. This transition may be facilitated by changes in expression of some B. burgdorferi genes. Spirochetal surface adhesions mediate attachment to decorin, a major component of the host extracellular matrix, enabling bacteria to colonize in mammalian tissues. It is believed that expression of the various proteins associated with the spirochete may be regulated by the changes in tick life cycle, changes in conditions during tick feeding (such as temperature, pH, and nutrients) and/or in coordination with the course of infection of the mammal host.
    Synonyms: Decorin-binding Protein A, Borrelia burgdorferi dbpA
    Gene ID
    1194347
    NCBI Accession
    NP_045697
    UniProt
    O50917
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