PNPLA2 antibody (C-Term)

Catalog No. ABIN965617

Product Details anti-PNPLA2 Antibody

Target: PNPLA2 (Patatin-Like phospholipase Domain Containing 2 (PNPLA2))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PNPLA2 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Purification: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ATGL(adipose triglyceride lipase)

Application Details

Application Notes: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for PNPLA2

Target: PNPLA2 (Patatin-Like phospholipase Domain Containing 2 (PNPLA2))

Alternative Name: ATGL (adipose triglyceride lipase) (PNPLA2 Products)

Synonyms: 1110001C14Rik antibody, ATGL antibody, PEDF-R antibody, TTS-2.2 antibody, TTS2 antibody, iPLA2zeta antibody, PNPLA2 antibody, pnpla2 antibody, 0610039C21Rik antibody, Atgl antibody, RGD1309044 antibody, patatin like phospholipase domain containing 2 antibody, patatin-like phospholipase domain containing 2 antibody, PNPLA2 antibody, pnpla2 antibody, Pnpla2 antibody

Background: ATGL(adipose triglyceride lipase) may function as a lipase and play a role in the adaptive response to a low energy state, such as fasting, by providing fatty acids to other tissues for oxidation. In addition, decreased expression of desnutrin in obesity models suggests its possible contribution to the pathophysiology of obesity. The adipose triglyceride lipase (ATGL) catalyzes the initial step in triglyceride hydrolysis. ATGL contains a patatin domain common to plant acyl-hydrolases. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals. The iPLA2epsilon (adiponutrin), iPLA2zeta (TTS2.2), and iPLA2eta (GS2) are three novel TAG lipases/acylglycerol transacylases that likely participate in TAG hydrolysis and the acyl-CoA independent transacylation of acylglycerols