Beclin 1 antibody

Catalog No. ABIN965657

There is 1 publication for this product available. The Mouse Monoclonal anti-Beclin 1 antibody has been validated for WB, IHC, ELISA and FACS. It is suitable to detect Beclin 1 in samples from Human.

Quick Overview for Beclin 1 antibody (ABIN965657)

Target: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Beclin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Clone: 2A4

Product Details anti-Beclin 1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human BECN1 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Format: Liquid

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

References for anti-Beclin 1 antibody (ABIN965657)

Pickford, Masliah, Britschgi, Lucin, Narasimhan, Jaeger, Small, Spencer, Rockenstein, Levine, Wyss-Coray: "The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice." in: The Journal of clinical investigation, Vol. 118, Issue 6, pp. 2190-9, (2008) (PubMed).

Target Details for Beclin 1

Target: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Alternative Name: BECN1

Background: Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 (PubMed 19270693)).(supplied by OMIM).
Tissue specificity: Ubiquitous.
Synonyms: ATG6, VPS30, beclin1, BECN1

Molecular Weight: 60kDa

Gene ID: 8678

Pathways: Autophagy