Endoglin antibody

Catalog No. ABIN965762

The Mouse Monoclonal anti-Endoglin antibody has been validated for WB, FACS, IHC, ELISA and IF. It is suitable to detect Endoglin in samples from Human. There are 2+ publications available.

Quick Overview for Endoglin antibody (ABIN965762)

Target: Endoglin (ENG)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Endoglin antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Clone: 3A9

Product Details anti-Endoglin Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human CD105 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
Immunofluorescence: 1/200 - 1/1000.
Flow cytometry: 1/200 - 1/400.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Format: Liquid

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

References for anti-Endoglin antibody (ABIN965762)

Fujita, Ewing, Chan, Mangold, Partin, Isaacs, Pavlovich: "Endoglin (CD105) as a urinary and serum marker of prostate cancer." in: International journal of cancer. Journal international du cancer, Vol. 124, Issue 3, pp. 664-9, (2008) (PubMed).

Sun: "Pharmacophore-based virtual screening." in: Current medicinal chemistry, Vol. 15, Issue 10, pp. 1018-24, (2008) (PubMed).

Target Details for Endoglin

Target: Endoglin (ENG)

Alternative Name: CD105

Background: This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia.
Synonyms: ENG, END, ORW, HHT1, ORW1, CD105, FLJ41744

Molecular Weight: 71kDa

Gene ID: 2022