CDK1 antibody

Catalog No. ABIN965840

The Mouse Monoclonal anti-CDK1 antibody has been validated for WB, IHC, ELISA and IF. It is suitable to detect CDK1 in samples from Human, Mouse, Rat and Monkey. There are 3+ publications available.

Quick Overview for CDK1 antibody (ABIN965840)

Target: CDK1 (Cyclin-Dependent Kinase 1 (CDK1))

Reactivity: Human, Mouse, Rat, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This CDK1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Clone: 5A6

Product Details anti-CDK1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human CDK1 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Format: Liquid

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

References for anti-CDK1 antibody (ABIN965840)

McMullin: "The classification and diagnosis of erythrocytosis." in: International journal of laboratory hematology, Vol. 30, Issue 6, pp. 447-59, (2008) (PubMed).

Marash, Liberman, Henis-Korenblit, Sivan, Reem, Elroy-Stein, Kimchi: "DAP5 promotes cap-independent translation of Bcl-2 and CDK1 to facilitate cell survival during mitosis." in: Molecular cell, Vol. 30, Issue 4, pp. 447-59, (2008) (PubMed).

Maas: "The potential for the formation of the arginine biosynthetic enzymes and its masking during evolution." in: BioEssays : news and reviews in molecular, cellular and developmental biology, Vol. 29, Issue 5, pp. 484-8, (2007) (PubMed).

Target Details for CDK1

Target: CDK1 (Cyclin-Dependent Kinase 1 (CDK1))

Alternative Name: CDK1

Background: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control.
Synonyms: CDC2, CDC28A, P34CDC2, MGC111195, DKFZp686L20222, CDK1

Molecular Weight: 34kDa

Gene ID: 983

Pathways: Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Toll-Like Receptors Cascades, Synthesis of DNA