CREB1 antibody

Catalog No. ABIN965927

Product Details anti-CREB1 Antibody

Target: CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CREB1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Specificity: CREB (Ab-133) antibody detects endogenous levels of total CREB protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: This antiserum was produced against synthesized non-phosphopeptide derived from human CREB around the phosphorylation site of serine 133 (R-P-SP-Y-R).

Application Details

Application Notes: WB: 1:500~1:1000
IHC: 1:50~1:100.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100ug/100ul.

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-CREB1 antibody (ABIN965927)

Westerheide, Mayo, Anest, Hanson, Baldwin: "The putative oncoprotein Bcl-3 induces cyclin D1 to stimulate G(1) transition." in: Molecular and cellular biology, Vol. 21, Issue 24, pp. 8428-36, (2001) (PubMed).

Xing, Kornhauser, Xia, Thiele, Greenberg: "Nerve growth factor activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways to stimulate CREB serine 133 phosphorylation." in: Molecular and cellular biology, Vol. 18, Issue 4, pp. 1946-55, (1998) (PubMed).

Rosenfeld, Correia, Xing, Rener, Cheung: "Structural studies of kinesin-nucleotide intermediates." in: The Journal of biological chemistry, Vol. 271, Issue 47, pp. 30212-21, (1997) (PubMed).

Tan, Rouse, Zhang, Cariati, Cohen, Comb: "FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2." in: The EMBO journal, Vol. 15, Issue 17, pp. 4629-42, (1997) (PubMed).

Hao, Lowy, Kapoor, Deffie, Liu, Lozano: "Mutation of phosphoserine 389 affects p53 function in vivo." in: The Journal of biological chemistry, Vol. 271, Issue 46, pp. 29380-5, (1997) (PubMed).

Target Details for CREB1

Target: CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))

Alternative Name: CREB (CREB1 Products)

Pathways: TLR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Cell Size, Toll-Like Receptors Cascades, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Positive Regulation of fat Cell Differentiation