Desmin antibody

Catalog No. ABIN965993

The Monoclonal anti-Desmin antibody has been validated for WB, IHC and ELISA. It is suitable to detect Desmin in samples from Human. There are 2+ publications available.

Quick Overview for Desmin antibody (ABIN965993)

Target: Desmin (DES)

Reactivity: Human

Host: Please inquire

Clonality: Monoclonal

Conjugate: This Desmin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-Desmin Antibody

Specificity: Ni-NTA purified truncated recombinant Desmin expressed in E. Coli strain BL21 (DE3)

Isotype: IgG1

Application Details

Application Notes: Western Blot: 1: 1,000- 1: 2,000
IHC(P): 1: 1,000- 1: 2,000
IHC(F): 1: 1,000- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Storage: -20 °C

References for anti-Desmin antibody (ABIN965993)

Shardonofsky, Capetanaki, Boriek: "Desmin modulates lung elastic recoil and airway responsiveness." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 290, Issue 5, pp. L890-6, (2006) (PubMed).

Huang, Li, Foster, Lemanski, Dube, Zhang, Lemanski: "Protein kinase C-mediated desmin phosphorylation is related to myofibril disarray in cardiomyopathic hamster heart." in: Experimental biology and medicine (Maywood, N.J.), Vol. 227, Issue 11, pp. 1039-46, (2002) (PubMed).

Target Details for Desmin

Target: Desmin (DES)

Alternative Name: Desmin

Background: Desmin (DES), with 470-amino acid protein (about 52kDa), belongs to the intermediate filament family and Desmin is class III intermediate filaments found in muscle cells. Homopolymers of Desmin form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane.Mutations in Desmin are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.Desmin is also expressed in smooth muscle cells of both airways and alveolar ducts and Desmin is a load-bearing protein that stiffens the airways and consequently the lung and modulates airway contractile response.

Gene ID: 1674