GPC1 antibody (C-Term)

Catalog No. ABIN966218

Product Details anti-GPC1 Antibody

Target: GPC1 (Glypican 1 (GPC1))

Binding Specificity: C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPC1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Purification: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human GPC1(Glypican-1 precursor)

Application Details

Application Notes: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-GPC1 antibody (ABIN966218)

Davies, Blackhall, Shanks, David, McGown, Swindell, Slade, Martin-Hirsch, Gallagher, Jayson: "Distribution and clinical significance of heparan sulfate proteoglycans in ovarian cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 10, Issue 15, pp. 5178-86, (2004) (PubMed).

Target Details for GPC1

Target: GPC1 (Glypican 1 (GPC1))

Alternative Name: GPC1 (GPC1 Products)

Synonyms: gpc1 antibody, zgc:63947 antibody, GPC1 antibody, Glypican-1 antibody, glypican antibody, AI462976 antibody, HSPG M12 antibody, HSPGM12 antibody, glypican 1b antibody, glypican 1 antibody, gpc1b antibody, GPC1 antibody, gpc1 antibody, Gpc1 antibody

Background: GPC1(Glypican-1) is a cell surface proteoglycan that bears heparan sulfate. The protein is attached to the membrane by a GPI-anchor. This cell-associated glypican is further processed to give rise to a medium-released species. The glypican-1 is required for efficient TGF-beta1 signaling in pancreatic cancer cells. The syndecan-1 and glypican-1 have roles in progression of ovarian cancer. Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.

Pathways: Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation