Interferon gamma antibody

Catalog No. ABIN966336

Cited in 1 publication. The Monoclonal anti-Interferon gamma antibody (ABIN966336) specifically detects Interferon gamma in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for Interferon gamma antibody (ABIN966336)

Target: Interferon gamma (IFNG)

Reactivity: Human

Host: Please inquire

Clonality: Monoclonal

Conjugate: This Interferon gamma antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Interferon gamma Antibody

Specificity: Ni-NTA purified recombinant human IFN-gamma expressed in E. Coli strain BL21 (DE3)

Purification: Antibodies are purified by protein A affinity chromatography

Isotype: IgG1

Application Details

Application Notes: Dilution: Western Blot: 1:500-1,000
ELISA: Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Storage: -20 °C

References for anti-Interferon gamma antibody (ABIN966336)

Tsubota, Fukagawa, Fujihara, Shimmura, Saito, Saito, Takeuchi: "Regulation of human leukocyte antigen expression in human conjunctival epithelium." in: Investigative ophthalmology & visual science, Vol. 40, Issue 1, pp. 28-34, (1999) (PubMed).

Target Details for Interferon gamma

Target: Interferon gamma (IFNG)

Alternative Name: IFN-Y

Background: Interferon-gamma (IFN-gamma) is a pro-inflammatory cytokine that is central in host resistance to infection. It is mainly produced by natural killer cells and CD4+ and CD8+ T cells, its receptors are found on nearly all cells, where it activates diverse responses that enable potential host cells to prevent invasive infection by bacteria, parasites and viruses. Takayanagi et al. (2000) demonstrated that IFN-gamma strongly suppresses osteoclastogenesis by interfering with the RANKL (602642)-RANK (603499) signaling pathway. Tsubota et al. (1999) reported that this upregulation in Sjogren syndrome patients may be controlled by interferon-gamma through the activation of transcription factor NFKB.

Gene ID: 3458

Pathways: Interferon-gamma Pathway, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy