Merlin antibody

Catalog No. ABIN966568

This Rabbit Polyclonal antibody specifically detects Merlin in IHC. It exhibits reactivity toward Human, Mouse and Rat and has been mentioned in 3+ publications.

Quick Overview for Merlin antibody (ABIN966568)

Target: Merlin (NF2) (Neurofibromin 2 (NF2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Merlin antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-Merlin Antibody

Specificity: Merlin (Ab-518) antibody detects endogenous levels of total Merlin protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human Merlin around the phosphorylation site of serine 518 (R-L-SP-M-E).

Application Details

Application Notes: WB: 1:500~1:1000.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100ug/100ul.

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-Merlin antibody (ABIN966568)

Xiao, Gallagher, Shetler, Skele, Altomare, Pestell, Jhanwar, Testa: "The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression." in: Molecular and cellular biology, Vol. 25, Issue 6, pp. 2384-94, (2005) (PubMed).

Ratner, Bryan, Weber, Nguyen, Barnes, Pitt, Gelber, Cheung, Prince: "Cystic fibrosis pathogens activate Ca2+-dependent mitogen-activated protein kinase signaling pathways in airway epithelial cells." in: The Journal of biological chemistry, Vol. 276, Issue 22, pp. 19267-75, (2001) (PubMed).

Böhni, Hemmi, Aguet: "Signaling steps involving the cytoplasmic domain of the interferon-gamma receptor alpha-subunit are not species-specific." in: The Journal of biological chemistry, Vol. 269, Issue 20, pp. 14541-5, (1994) (PubMed).

Target Details for Merlin

Target: Merlin (NF2) (Neurofibromin 2 (NF2))

Alternative Name: Merlin

Pathways: Cell-Cell Junction Organization