P-Cadherin antibody (AA 612-626)

Catalog No. ABIN966724

This Polyclonal antibody specifically detects P-Cadherin in WB, ICC and IHC (p). It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for P-Cadherin antibody (AA 612-626) (ABIN966724)

Target: P-Cadherin (CDH3)

Reactivity: Human

Host: Please inquire

Clonality: Polyclonal

Conjugate: This P-Cadherin antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-P-Cadherin Antibody

Binding Specificity: AA 612-626

Immunogen: A synthetic peptide corresponding to a sequence at the middle region of human P-Cadherin (612-626 aa), different from the mouse and rat sequence by one amino acid.

Application Details

Application Notes: WB: The detection limit for P-Cadherin is approximately 2.5ng/lane under non-reducing and reducing conditions.

Restrictions: For Research Use only

Handling

Reconstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Preservative: Thimerosal (Merthiolate), Sodium azide

Storage: -20 °C

References for anti-P-Cadherin antibody (ABIN966724)

Kaupmann, Becker-Follmann, Scherer, Jockusch, Starzinski-Powitz: "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species." in: Genomics, Vol. 14, Issue 2, pp. 488-90, (1992) (PubMed).

Target Details for P-Cadherin

Target: P-Cadherin (CDH3)

Alternative Name: P-Cadherin

Background: Cadherins, such as CDH3, are integral membrane glycoproteins responsible for calcium-dependent cell-cell adhesion. Cadherin-3 is a protein that in humans is encoded by the CDH3 gene. This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.