SRA1 antibody (Steroid Receptor RNA Activator 1)

Details for Product anti-SRA1 Antibody No. ABIN967076
Antigen
  • SRA
  • SRAP
  • STRAA1
  • pp7684
  • AA959952
  • Sra
  • Srap
  • Straa1
  • Strra1
  • zgc:86613
  • steroid receptor RNA activator 1
  • steroid receptor RNA activator 1 S homeolog
  • SRA1
  • Sra1
  • sra1
  • sra1.S
Alternatives
anti-Human SRA1 antibody for Western Blotting
Reactivity
Human
59
7
7
4
4
4
3
2
2
Host
38
21
Clonality
Monoclonal
Conjugate
This SRA1 antibody is un-conjugated
2
2
2
2
2
2
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
60
41
18
7
2
1
Options
Isotype IgG1
Specificity Ni-NTA purified truncated recombinant SRA expressed in E. Coli strain BL21 (DE3)
Purification Crude ascites.
Plasmids, Primers & others Plasmids, Primers & others SRA1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name SRA (SRA1 Antibody Abstract)
Background Steroid receptor RNA activator 1 (SRA), with 237-amino acid protein (about 27kDa), belongs to the growing family of functional non-coding RNAs. SRA was originally described as the first functional noncoding RNA able to specifically coactivate the activity of steroid receptors. Specifically, SRA exists as both an RNA transcript that forms a complex with steroid receptor coactivator-1 and as a stably expressed protein. Its expression is strongly up-regulated in many human tumors of the breast, uterus, and ovary, suggesting a potential role in pathogenesis. Although coactivation of steroid-dependent transcription by SRA is accompanied by a proliferative response, overexpression is not in itself sufficient to induce turmorigenesis.
Gene ID 10011
Pathways EGFR Signaling Pathway, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development
Application Notes Western Blot: 1: 500- 1: 2,000
IHC(P): 1: 500- 1: 2,000
IHC(F): 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000 Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Storage -20 °C
Product cited in: Chooniedass-Kothari, Hamedani, Troup, Hubé, Leygue: "The steroid receptor RNA activator protein is expressed in breast tumor tissues." in: International journal of cancer. Journal international du cancer, Vol. 118, Issue 4, pp. 1054-9, 2006 (PubMed).

Chooniedass-Kothari, Emberley, Hamedani, Troup, Wang, Czosnek, Hube, Mutawe, Watson, Leygue: "The steroid receptor RNA activator is the first functional RNA encoding a protein." in: FEBS letters, Vol. 566, Issue 1-3, pp. 43-7, 2004 (PubMed).

Lanz, Chua, Barron, Söder, DeMayo, OMalley: "Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo." in: Molecular and cellular biology, Vol. 23, Issue 20, pp. 7163-76, 2003 (PubMed).

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