Src antibody

Catalog No. ABIN967081

This Rabbit Polyclonal antibody specifically detects Src in IHC. It exhibits reactivity toward Human, Mouse and Rat. It has been mentioned in 5+ publications

Quick Overview for Src antibody (ABIN967081)

Target: Src (Proto-oncogene tyrosine-protein kinase Src (Src))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Src antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-Src Antibody

Specificity: Src (Ab-418) antibody detects endogenous levels of total Src protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human Src around the phosphorylation site of tyrosine 418 (N-E-YP-T-A).

Application Details

Application Notes: WB: 1:500~1:1000.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100ug/100ul.

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-Src antibody (ABIN967081)

David-Dufilho, Millanvoye-Van Brussel, Topal, Walch, Brunet, Rendu: "Endothelial thrombomodulin induces Ca2+ signals and nitric oxide synthesis through epidermal growth factor receptor kinase and calmodulin kinase II." in: The Journal of biological chemistry, Vol. 280, Issue 43, pp. 35999-6006, (2005) (PubMed).

Sanders, Basson: "p130cas but not paxillin is essential for Caco-2 intestinal epithelial cell spreading and migration on collagen IV." in: The Journal of biological chemistry, Vol. 280, Issue 25, pp. 23516-22, (2005) (PubMed).

Murugappan, Shankar, Bhamidipati, Dorsam, Jin, Kunapuli: "Molecular mechanism and functional implications of thrombin-mediated tyrosine phosphorylation of PKCdelta in platelets." in: Blood, Vol. 106, Issue 2, pp. 550-7, (2005) (PubMed).

Gu, Santiago, Mitchell: "Synergy between imatinib and mycophenolic acid in inducing apoptosis in cell lines expressing Bcr-Abl." in: Blood, Vol. 105, Issue 8, pp. 3270-7, (2005) (PubMed).

Zhou, Schmelz, Seufferlein, Li, Zhao, Bachem: "Molecular mechanisms of low intensity pulsed ultrasound in human skin fibroblasts." in: The Journal of biological chemistry, Vol. 279, Issue 52, pp. 54463-9, (2004) (PubMed).

Target Details for Src

Target: Src (Proto-oncogene tyrosine-protein kinase Src (Src))

Alternative Name: Src

Pathways: JAK-STAT Signaling, Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization, Regulation of Carbohydrate Metabolic Process, Autophagy, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling, Platelet-derived growth Factor Receptor Signaling, Thromboxane A2 Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling