Src antibody

Catalog No. ABIN967082

The Rabbit Polyclonal anti-Src antibody has been validated for IHC. It is suitable to detect Src in samples from Human, Mouse and Rat. There are 4+ publications available.

Quick Overview for Src antibody (ABIN967082)

Target: Src (Proto-oncogene tyrosine-protein kinase Src (Src))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Src antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-Src Antibody

Specificity: Src (Ab-529) antibody detects endogenous levels of total Src protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human Src around the phosphorylation site of tyrosine 529 (P-Q-YP-Q-P).

Application Details

Application Notes: WB: 1:500~1:1000
IHC: 1:50~1:100.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 100ug/100ul.

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-Src antibody (ABIN967082)

Benes, Wu, Elia, Dharia, Cantley, Soltoff: "The C2 domain of PKCdelta is a phosphotyrosine binding domain." in: Cell, Vol. 121, Issue 2, pp. 271-80, (2005) (PubMed).

Xu, Harrison, Eck: "Three-dimensional structure of the tyrosine kinase c-Src." in: Nature, Vol. 385, Issue 6617, pp. 595-602, (1997) (PubMed).

Pyper, Bolen: "Identification of a novel neuronal C-SRC exon expressed in human brain." in: Molecular and cellular biology, Vol. 10, Issue 5, pp. 2035-40, (1990) (PubMed).

Parker, Mardon, Lebo, Varmus, Bishop: "Isolation of duplicated human c-src genes located on chromosomes 1 and 20." in: Molecular and cellular biology, Vol. 5, Issue 4, pp. 831-8, (1985) (PubMed).

Target Details for Src

Target: Src (Proto-oncogene tyrosine-protein kinase Src (Src))

Alternative Name: Src

Pathways: JAK-STAT Signaling, Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization, Regulation of Carbohydrate Metabolic Process, Autophagy, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling, Platelet-derived growth Factor Receptor Signaling, Thromboxane A2 Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling