TIMP3 antibody (N-Term)

Catalog No. ABIN967183

This Rabbit Polyclonal antibody specifically detects TIMP3 in IHC. It exhibits reactivity toward Human and Xenopus laevis.

Quick Overview for TIMP3 antibody (N-Term) (ABIN967183)

Target: TIMP3 (TIMP Metallopeptidase Inhibitor 3 (TIMP3))

Reactivity: Human, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIMP3 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-TIMP3 Antibody

Binding Specificity: N-Term

Purification: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of African clawed frog TIMP3(Metalloproteinase inhibitor 3 precursor)

Application Details

Application Notes: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for TIMP3

Target: TIMP3 (TIMP Metallopeptidase Inhibitor 3 (TIMP3))

Alternative Name: TIMP3

Background: TIMP3(Metalloproteinase inhibitor 3) complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. TIMP3 may form part of a tissue-specific acute response to remodeling stimuli. TIMP3 is known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. Defects in TIMP3 are the cause of Sorsby's fundus dystrophy (SFD). SFD is a rare autosomal dominant macular disorder with an age of onset in the fourth decade. It is characterized by loss of central vision from subretinal neovascularization and atrophy of the occular tissues.