NAMPT antibody

Catalog No. ABIN967254

Product Details anti-NAMPT Antibody

Target: NAMPT (Nicotinamide phosphoribosyltransferase (NAMPT))

Reactivity: Human

Host: Please inquire

Clonality: Monoclonal

Conjugate: This NAMPT antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: Ni-NTA purified truncated recombinant Visfatin expressed in E. Coli strain BL21 (DE3)

Purification: Antibodies are purified by protein A affinity chromatography

Isotype: IgG1

Application Details

Application Notes: Western Blot: Dilution 1: 2,00- 1: 1,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Storage: -20 °C

References for anti-NAMPT antibody (ABIN967254)

Jin, Zhuo, Guo, Field: "p21-activated Kinase 1 (Pak1)-dependent phosphorylation of Raf-1 regulates its mitochondrial localization, phosphorylation of BAD, and Bcl-2 association." in: The Journal of biological chemistry, Vol. 280, Issue 26, pp. 24698-705, (2005) (PubMed).

Antignani, Youle: "A chimeric protein induces tumor cell apoptosis by delivering the human Bcl-2 family BH3-only protein Bad." in: Biochemistry, Vol. 44, Issue 10, pp. 4074-82, (2005) (PubMed).

Target Details for NAMPT

Target: NAMPT (Nicotinamide phosphoribosyltransferase (NAMPT))

Alternative Name: Visfatin (NAMPT Products)

Synonyms: 1110035O14Rik antibody, PBEF antibody, PBEF1 antibody, VF antibody, VISFATIN antibody, AI314458 antibody, AI480535 antibody, NAmPRTase antibody, Pbef antibody, Pbef1 antibody, Visfatin antibody, visfatin antibody, pbef antibody, pbef1 antibody, nicotinamide phosphoribosyltransferase antibody, Nicotinamide phosphoribosyltransferase antibody, nicotinamide phosphoribosyltransferase S homeolog antibody, NAMPT antibody, Nampt antibody, nampt antibody, Smon_0680 antibody, Mrub_2845 antibody, Cseg_3704 antibody, BC1002_3997 antibody, Ftrac_2686 antibody, Varpa_5681 antibody, Celal_3900 antibody, Deima_0880 antibody, BC1001_3724 antibody, Celly_1696 antibody, Clole_1542 antibody, Tsp_05934 antibody, nampt.S antibody

Background: Visfatin, a newly identified adipocytokine ,which is predominantly secreted from visceral adipose tissue both in humans and mice . Visfatin corresponds to a protein identified previously as pre-B cell colony-enhancing factor (PBEF). Visfatin exerted insulin-mimetic effects in cultured cells, various insulin-sensitive tissues such as liver, muscle, and fat ,and lowered plasma glucose levels in mice. Mice heterozygous for a targeted mutation in the visfatin gene had modestly higher levels of plasma glucose relative to wild-type littermates. visfatin binds to and activates the insulin receptor. Which may lead to new insights into glucose homeostasis and/or new therapies for metabolic disorders such as diabetes.

Gene ID: 10135