Integrin beta 3 antibody
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- Target See all Integrin beta 3 (ITGB3) Antibodies
- Integrin beta 3 (ITGB3)
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Reactivity
- Human, Cow, Baboon, Cynomolgus, Rhesus Monkey
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This Integrin beta 3 antibody is un-conjugated
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Application
- Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Brand
- BD Pharmingen™
- Characteristics
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Clone
- VI-PL2
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product ITGB3 Primary Antibody
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Buffer
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C
- Storage Comment
- Store undiluted at 4° C.
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CD antigens 2001." in: Tissue antigens, Vol. 58, Issue 6, pp. 425-30, (2002) (PubMed).
: "
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CD antigens 2001." in: Tissue antigens, Vol. 58, Issue 6, pp. 425-30, (2002) (PubMed).
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- Target
- Integrin beta 3 (ITGB3)
- Alternative Name
- CD61 (ITGB3 Products)
- Background
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Reacts with integrin beta3, a 105 kDa transmembrane glycoprotein, expressed on platelets, megakaryocytes, osteoclasts and endothelia. Integrin beta3 associates with gpIIa (CD41) to form the CD41/CD61 complex which mediates platelet adhesion and aggregation. CD61 also associates with CD51 to form the CD51/CD61 complex (vitronectin receptor). CD61 appears to bind to fibrinogen, fibronectin, vWF, vitronectin, and thrombospondin to mediate cell adhesion. This antibody is routinely tested by flow cytometric analysis.
Synonyms: Integrin beta3 Chain - Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex
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