Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

STXBP1 antibody (AA 18-1)

STXBP1 Reactivity: Human, Mouse, Rat WB, IHC, IF, IP Host: Mouse Monoclonal 31-Munc unconjugated
Catalog No. ABIN967911
  • Target See all STXBP1 Antibodies
    STXBP1 (Syntaxin Binding Protein 1 (STXBP1))
    Binding Specificity
    • 15
    • 6
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 18-1
    Reactivity
    • 48
    • 42
    • 31
    • 7
    • 6
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 59
    • 6
    • 2
    Mouse
    Clonality
    • 61
    • 6
    Monoclonal
    Conjugate
    • 40
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This STXBP1 antibody is un-conjugated
    Application
    • 51
    • 27
    • 13
    • 13
    • 13
    • 10
    • 8
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
    Cross-Reactivity
    Mouse (Murine), Human
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Rat Munc-18-1 aa. 381-567
    Clone
    31-Munc
    Isotype
    IgG1
    Top Product
    Discover our top product STXBP1 Primary Antibody
  • Comment

    Related Products: ABIN968545, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20°C.
  • Curtis, Doneske, Liu, Thaller, McNew, Janz: "Syntaxin 3b is a t-SNARE specific for ribbon synapses of the retina." in: The Journal of comparative neurology, Vol. 510, Issue 5, pp. 550-9, (2008) (PubMed).

    Torii, Zhao, Yi, Takeuchi, Izumi: "Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a." in: Molecular and cellular biology, Vol. 22, Issue 15, pp. 5518-26, (2002) (PubMed).

    Fisher, Pevsner, Burgoyne: "Control of fusion pore dynamics during exocytosis by Munc18." in: Science (New York, N.Y.), Vol. 291, Issue 5505, pp. 875-8, (2001) (PubMed).

    Zhang, Efanov, Yang, Fried, Kolare, Brown, Zaitsev, Berggren, Meister: "Munc-18 associates with syntaxin and serves as a negative regulator of exocytosis in the pancreatic beta -cell." in: The Journal of biological chemistry, Vol. 275, Issue 52, pp. 41521-7, (2001) (PubMed).

    Shuang, Zhang, Fletcher, Groblewski, Pevsner, Stuenkel: "Regulation of Munc-18/syntaxin 1A interaction by cyclin-dependent kinase 5 in nerve endings." in: The Journal of biological chemistry, Vol. 273, Issue 9, pp. 4957-66, (1998) (PubMed).

    Hata, Slaughter, Südhof: "Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin." in: Nature, Vol. 366, Issue 6453, pp. 347-51, (1993) (PubMed).

  • Target
    STXBP1 (Syntaxin Binding Protein 1 (STXBP1))
    Alternative Name
    Munc-18 (STXBP1 Products)
    Synonyms
    MUNC18-1 antibody, NSEC1 antibody, P67 antibody, RBSEC1 antibody, UNC18 antibody, AI317162 antibody, AI326233 antibody, MMS10-G antibody, Ms10g antibody, Munc-18a antibody, Munc18-1 antibody, N-sec1 antibody, Rb-sec1 antibody, Sxtbp1 antibody, Unc18-1 antibody, Unc18h antibody, nsec1 antibody, fj43h10 antibody, stxbp1 antibody, wu:fj36d12 antibody, wu:fj43h10 antibody, zgc:114171 antibody, rop antibody, unc18 antibody, hunc18 antibody, rbsec1 antibody, munc18-1 antibody, MGC146482 antibody, ANC18HA antibody, NSEC1A antibody, Sec1 antibody, n-sec1 antibody, nSec1 antibody, rbSec1 antibody, rbSec1A antibody, rbSec1B antibody, UNC18A antibody, si:rp71-10d23.3 antibody, syntaxin binding protein 1 antibody, syntaxin binding protein 1a antibody, syntaxin binding protein 1 L homeolog antibody, syntaxin binding protein 1b antibody, STXBP1 antibody, Stxbp1 antibody, stxbp1a antibody, stxbp1 antibody, Tb09.160.0780 antibody, stxbp1.L antibody, stxbp1b antibody
    Background
    There are two Munc-18 isoforms: Munc-18-1 and Munc-18-2. Munc-18-1 (n-sec1 or rb-sec1, 68 kDa) is a neuronal protein that binds tightly to syntaxin 1 and functions in synaptic vesicle exocytosis. Munc-18-2 exhibits 63% amino acid sequence identity with Munc-18-1. Although Munc-18-2 is expressed in most tissues, Munc-18-1 is primarily expressed in brain. Both forms of Munc-18 bind tightly to syntaxins 1A, 2, and 3, but not to syntaxin 4. Syntaxin 1A is a plasma membrane protein implicated in synaptic vesicle docking. Following calcium entry into the presynaptic nerve terminal, the neurotransmitter-containing synaptic vesicle fuses with the plasma membrane at a region known as the active zone. Thus, by virtue of its interaction with syntaxin 1A, Munc-18-1 is thought to have an essential function in neurotransmitter release.
    Molecular Weight
    68 kDa
    Pathways
    Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
You are here:
Support