FKBP10 antibody (AA 434-576)

Catalog No. ABIN968087

The Mouse Monoclonal anti-FKBP10 antibody has been validated for WB, IHC, IP and IF. It is suitable to detect FKBP10 in samples from Human, Mouse and Rat. There are 2+ publications available.

Quick Overview for FKBP10 antibody (AA 434-576) (ABIN968087)

Target: FKBP10 (FK506 Binding Protein 10, 65 KDa (FKBP10))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This FKBP10 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Clone: 25-FKBP65

Product Details anti-FKBP10 Antibody

Binding Specificity: AA 434-576

Cross-Reactivity: Rat (Rattus), Human

Characteristics: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse FKBP65 aa. 434-576

Isotype: IgG1

Application Details

Comment:

Related Products: ABIN967389, ABIN968539

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store undiluted at -20°C.

References for anti-FKBP10 antibody (ABIN968087)

Patterson, Schaub, Coleman, Davis: "Developmental regulation of FKBP65. An ER-localized extracellular matrix binding-protein." in: Molecular biology of the cell, Vol. 11, Issue 11, pp. 3925-35, (2001) (PubMed).

Coss, Winterstein, Sowder, Simek: "Molecular cloning, DNA sequence analysis, and biochemical characterization of a novel 65-kDa FK506-binding protein (FKBP65)." in: The Journal of biological chemistry, Vol. 270, Issue 49, pp. 29336-41, (1996) (PubMed).

Target Details for FKBP10

Target: FKBP10 (FK506 Binding Protein 10, 65 KDa (FKBP10))

Alternative Name: FKBP65

Background: FK506, one of multiple potent compounds that block T cell proliferation, is used for immunosuppressive therapy. Several FK506-binding proteins (FKBPs) have been identified in the search for intracellular targets for FK506. These include FKBP12, FKBP13, FKBP51, and FKBP52. The immunosuppressive effects of FK506 and FKBPs result from the inhibition of the calcineurin phosphatase, a well known component of the signaling cascade leading to IL-2 production. FKBP65 is another member of the FKBP protein family and contains the characteristic peptidylprolyl cis-trans-isomerase activity. FKBP65 has been reported to be expressed in the lung, testis, brain, heart, and spleen. Although it has a predicted molecular weight of 65 kDa, FKBP65 has been observed to migrate ranging from 68-72 kDa in SDS electrophoresis gels, perhaps, due to glycosylation and/or phosphorylation.
Synonyms: FK506 Binding Protein-65

Molecular Weight: 68-72 kDa

Pathways: SARS-CoV-2 Protein Interactome