Annexin VII antibody (AA 34-159)

Catalog No. ABIN968099

There are 5+ publications for this product available. The Mouse Monoclonal anti-Annexin VII antibody is suitable to detect Annexin VII in samples from Human. It has been validated for WB, IHC, IF and IP.

Quick Overview for Annexin VII antibody (AA 34-159) (ABIN968099)

Target: Annexin VII (ANXA7) (Annexin A7 (ANXA7))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Annexin VII antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: 5-Annexin VII

Product Details anti-Annexin VII Antibody

Binding Specificity: AA 34-159

Characteristics: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human Annexin VII aa. 34-159

Isotype: IgG1

Application Details

Comment:

Related Products: ABIN968536, ABIN967389

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store undiluted at -20° C.

References for anti-Annexin VII antibody (ABIN968099)

Salzer, Hinterdorfer, Hunger, Borken, Prohaska: "Ca(++)-dependent vesicle release from erythrocytes involves stomatin-specific lipid rafts, synexin (annexin VII), and sorcin." in: Blood, Vol. 99, Issue 7, pp. 2569-77, (2002) (PubMed).

Srivastava, Bubendorf, Srikantan, Fossom, Nolan, Glasman, Leighton, Fehrle, Pittaluga, Raffeld, Koivisto, Willi, Gasser, Kononen, Sauter, Kallioniemi, Srivastava, Pollard: "ANX7, a candidate tumor suppressor gene for prostate cancer." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 8, pp. 4575-80, (2001) (PubMed).

Furge, Chen, Cohen: "Annexin VII and annexin XI are tyrosine phosphorylated in peroxovanadate-treated dogs and in platelet-derived growth factor-treated rat vascular smooth muscle cells." in: The Journal of biological chemistry, Vol. 274, Issue 47, pp. 33504-9, (1999) (PubMed).

Selbert, Fischer, Pongratz, Stewart, Noegel: "Expression and localization of annexin VII (synexin) in muscle cells." in: Journal of cell science, Vol. 108 ( Pt 1), pp. 85-95, (1995) (PubMed).

Magendzo, Shirvan, Cultraro, Srivastava, Pollard, Burns: "Alternative splicing of human synexin mRNA in brain, cardiac, and skeletal muscle alters the unique N-terminal domain." in: The Journal of biological chemistry, Vol. 266, Issue 5, pp. 3228-32, (1991) (PubMed).

Target Details for Annexin VII

Target: Annexin VII (ANXA7) (Annexin A7 (ANXA7))

Alternative Name: Annexin VII

Background: Annexin VII, also known as synexin, is a member of the Annexin family characterized by Ca2+ dependent phospholipid binding. Annexins have a four-fold internal repeat of about 70 amino acids that contains the Ca2+-binding sites. They also have a regulatory NH2-terminal region of 30-40 amino acids. Annexin VII mRNA has been detected in many tissues and is most abundant in brain, heart, skeletal muscle, and lung. Annexin VII mRNA exhibits a tissue dependent polymorphism due to alternative splicing which results in two different isoforms of 47 kDa and 51 kDa. In vitro, Annexin VII aggregates chromaffin granules and enhances membrane fusion in a Ca2+ and GTP-dependent manner. Although the physiological role of Annexin VII is not completely understood, it is believed to influence and regulate Ca2+ dependent events such as secretion at the plasma membrane.
Synonyms: Synexin

Molecular Weight: 51 kDa