Thymopoietin antibody (AA 34-156)

Catalog No. ABIN968307

Product Details anti-Thymopoietin Antibody

Target: Thymopoietin (TMPO)

Binding Specificity: AA 34-156

Reactivity: Human, Mouse, Rat, Dog

Host: Mouse

Clonality: Monoclonal

Conjugate: This Thymopoietin antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Cross-Reactivity: Mouse (Murine), Human, Dog (Canine)

Characteristics: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Rat LAP2 aa. 34-156

Clone: 27-LAP2

Isotype: IgG1

Application Details

Comment:

Related Products: ABIN967389

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store undiluted at -20° C.

References for anti-Thymopoietin antibody (ABIN968307)

Kimura, Ito, Watanabe, Takahashi, Ikawa, Yomogida, Fujita, Ikeuchi, Asada, Matsumiya, Okuyama, Okabe, Toshimori, Nakano: "Mouse germ cell-less as an essential component for nuclear integrity." in: Molecular and cellular biology, Vol. 23, Issue 4, pp. 1304-15, (2003) (PubMed).

Rusan, Tulu, Fagerstrom, Wadsworth: "Reorganization of the microtubule array in prophase/prometaphase requires cytoplasmic dynein-dependent microtubule transport." in: The Journal of cell biology, Vol. 158, Issue 6, pp. 997-1003, (2002) (PubMed).

Dechat, Gotzmann, Stockinger, Harris, Talle, Siekierka, Foisner: "Detergent-salt resistance of LAP2alpha in interphase nuclei and phosphorylation-dependent association with chromosomes early in nuclear assembly implies functions in nuclear structure dynamics." in: The EMBO journal, Vol. 17, Issue 16, pp. 4887-902, (1998) (PubMed).

Furukawa, Fritze, Gerace: "The major nuclear envelope targeting domain of LAP2 coincides with its lamin binding region but is distinct from its chromatin interaction domain." in: The Journal of biological chemistry, Vol. 273, Issue 7, pp. 4213-9, (1998) (PubMed).

Furukawa, Panté, Aebi, Gerace: "Cloning of a cDNA for lamina-associated polypeptide 2 (LAP2) and identification of regions that specify targeting to the nuclear envelope." in: The EMBO journal, Vol. 14, Issue 8, pp. 1626-36, (1995) (PubMed).

Target Details for Thymopoietin

Target: Thymopoietin (TMPO)

Alternative Name: LAP2 (TMPO Products)

Synonyms: LAP2 antibody, CMD1T antibody, LEMD4 antibody, PRO0868 antibody, TP antibody, lap2 antibody, LAP2beta antibody, 5630400D24Rik antibody, AI195756 antibody, AI606875 antibody, AW214352 antibody, AW547477 antibody, tmpo antibody, wu:fc26f12 antibody, wu:fd21f02 antibody, wu:fi29h05 antibody, thymopoietin antibody, thymopoietin S homeolog antibody, thymopoietin a antibody, TMPO antibody, Tmpo antibody, tmpo.S antibody, tmpoa antibody

Background: A specialized extension of the ER, the nuclear envelope (NE) forms the nuclear compartment boundary in eukaryotic cells. It contains numerous pore complexes and the nucleoplasmic side is linked to nuclear lamina. The nuclear lamina composes the structural framework for the NE and serves as a chromatin anchor site, thus, playing a major role in interphase nuclear organization. Many proteins are associated with lamina, particularly the LAPs (Lamina-Associated Polypeptides). LAP2 (also known as LAP2beta) is a hydrophilic protein with a single transmembrane segment near the C-terminus. Thus, it has been defined as a type II integral membrane protein with the majority of its structure exposed to the nucleoplasm. LAP2 binding to lamins contributes to the attachment of the nuclear lamina to the inner nuclear membrane. LAP2 also binds to chromatin, implying its role in chromosomal organization during mitosis. Mitotic phosphorylation of LAP2 regulates its binding to lamins and chromosomes during the disassembly and reassembly of mitosis. Thus, LAP2 is a nuclear protein that plays a role in the organization of the NE during cell cycle progression.
Synonyms: LAP2beta, Lamina-Associated Polypeptides

Molecular Weight: 53 kDa