Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

SRPK2 antibody (AA 363-485)

SRPK2 Reactivity: Human, Mouse, Rat, Dog WB, IF Host: Mouse Monoclonal 23-SRPK2 unconjugated
Catalog No. ABIN968376
  • Target See all SRPK2 Antibodies
    SRPK2 (SFRS Protein Kinase 2 (SRPK2))
    Binding Specificity
    • 15
    • 7
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    AA 363-485
    Reactivity
    • 50
    • 32
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat, Dog
    Host
    • 48
    • 2
    Mouse
    Clonality
    • 50
    Monoclonal
    Conjugate
    • 16
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This SRPK2 antibody is un-conjugated
    Application
    • 23
    • 21
    • 18
    • 14
    • 13
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Cross-Reactivity
    Mouse (Murine), Rat (Rattus), Dog (Canine)
    Characteristics
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    Purification
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human SRPK2 aa. 363-485
    Clone
    23-SRPK2
    Isotype
    IgG1
    Top Product
    Discover our top product SRPK2 Primary Antibody
  • Comment

    Related Products: ABIN968533, ABIN967389

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store undiluted at -20° C.
  • Wang, Lin, Dyck, Yeakley, Songyang, Cantley, Fu: "SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells." in: The Journal of cell biology, Vol. 140, Issue 4, pp. 737-50, (1998) (PubMed).

  • Target
    SRPK2 (SFRS Protein Kinase 2 (SRPK2))
    Alternative Name
    SRPK2 (SRPK2 Products)
    Synonyms
    SFRSK2 antibody, AW226533 antibody, AW492537 antibody, AW547358 antibody, Wbp6 antibody, mSRPK2 antibody, sfrsk2 antibody, srpk2 antibody, srpk2-b antibody, srpk2b antibody, SRSF protein kinase 2 antibody, serine/arginine-rich protein specific kinase 2 antibody, SRSF protein kinase 2 L homeolog antibody, SRPK2 antibody, Srpk2 antibody, srpk2 antibody, srpk2.L antibody
    Background
    Mammalian cell pre-mRNA splicing is mediated by the spliceosome, a multi-component complex that contains two types of splicing factors: small nuclear ribonucleoprotein particles (snRNPs) and non-snRNP factors. Interactions between snRNPs and pre-mRNA ensures proper establishment of a catalytic core for the splicing reaction. However, these interactions are mediated by the non-snRNP factors. The superfamily of Arg/Ser-rich (RS) domain containing splicing factors are well known non-snRNPs. All of these proteins share a similar structure consisting of an N-terminal RNA recognition motif and a C-terminal RS domain. However, different SR factors have distinct specificities and their function is regulated by their level of expression and by reversible phosphorylation. Two families of kinases phosphorylate RS domain-containing proteins: SR protein-specific kinases (SRPK1 and 2) and Clk/Sty. SRPK1 is predominate in the pancreas, whereas SRPK2 is highly expressed in brain. SRPK2 contains an N-terminal proline-rich sequence that mediates its in vitro interaction with a WW domain containing protein. SRPKs affect splice-site selection and are thought to affect alternative splicing. This antibody is routinely tested by western blot analysis.
    Synonyms: SR Protein specific Kinase-2
    Molecular Weight
    115 kDa
    Pathways
    Ribonucleoprotein Complex Subunit Organization
You are here:
Support