ABL1 antibody (AA 577-650)

Catalog No. ABIN968942

There is 1 publication for this product available. The Mouse Monoclonal anti-ABL1 antibody is suitable to detect ABL1 in samples from Human. It has been validated for ELISA.

Quick Overview for ABL1 antibody (AA 577-650) (ABIN968942)

Target: ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ABL1 antibody is un-conjugated

Application: ELISA

Clone: 7B11D6

Product Details anti-ABL1 Antibody

Binding Specificity: AA 577-650

Purpose: ABL1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of ABL1 (aa577-650) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-ABL1 antibody (ABIN968942)

Lu, Finnis, Xiang, Lee, Markowitz, Okhrimenko, Brodie: "Tyrosine 311 is phosphorylated by c-Abl and promotes the apoptotic effect of PKCdelta in glioma cells." in: Biochemical and biophysical research communications, Vol. 352, Issue 2, pp. 431-6, (2006) (PubMed).

Target Details for ABL1

Target: ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

Alternative Name: ABL1

Background: ABL1: c-abl oncogene 1, receptor tyrosine kinase. The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9,22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11.

Gene ID: 25

UniProt: P00519

Pathways: Apoptosis, Regulation of Muscle Cell Differentiation, Platelet-derived growth Factor Receptor Signaling, Lipid Metabolism