ARNTL antibody

Catalog No. ABIN968967

Cited in 3+ publications. The Mouse Monoclonal anti-ARNTL antibody (Clone 1C5) (ABIN968967) specifically detects ARNTL in ELISA and IHC. The antibody is reactive with Human samples.

Quick Overview for ARNTL antibody (ABIN968967)

Target: ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ARNTL antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Clone: 1C5

Product Details anti-ARNTL Antibody

Purpose: ARNTL Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human ARNTL expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-ARNTL antibody (ABIN968967)

Yosifova, Mushiroda, Stoianov, Vazharova, Dimova, Karachanak, Zaharieva, Milanova, Madjirova, Gerdjikov, Tolev, Velkova, Kirov, Owen, ODonovan, Toncheva, Nakamura: "Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population." in: Journal of affective disorders, Vol. 117, Issue 1-2, pp. 87-97, (2009) (PubMed).

Lee, Lee, Lee, Park, Kang, Chung, Lee, Kim: "Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex." in: Molecular and cellular biology, Vol. 28, Issue 19, pp. 6056-65, (2008) (PubMed).

Motzkus, Loumi, Cadenas, Vinson, Forssmann, Maronde: "Activation of human period-1 by PKA or CLOCK/BMAL1 is conferred by separate signal transduction pathways." in: Chronobiology international, Vol. 24, Issue 5, pp. 783-92, (2007) (PubMed).

Target Details for ARNTL

Target: ARNTL (Aryl Hydrocarbon Receptor Nuclear Translocator-Like (ARNTL))

Alternative Name: ARNTL

Background: The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene.

Molecular Weight: 68.7 kDa

UniProt: O00327

Pathways: Regulation of Lipid Metabolism by PPARalpha, Protein targeting to Nucleus, Warburg Effect