Beclin 1 antibody

Catalog No. ABIN968976

Cited in 2+ publications. The Mouse Monoclonal anti-Beclin 1 antibody (Clone 2A4) (ABIN968976) specifically detects Beclin 1 in WB, IHC, ELISA and FACS. The antibody is reactive with Human samples.

Quick Overview for Beclin 1 antibody (ABIN968976)

Target: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Beclin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Clone: 2A4

Product Details anti-Beclin 1 Antibody

Purpose: BECN1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human BECN1 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Beclin 1 antibody (ABIN968976)

Moore, Abourizk: "Necrobiosis lipoidica: an important cutaneous manifestation of diabetes that may respond to antiplatelet therapy." in: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, Vol. 14, Issue 7, pp. 947-8, (2008) (PubMed).

Pickford, Masliah, Britschgi, Lucin, Narasimhan, Jaeger, Small, Spencer, Rockenstein, Levine, Wyss-Coray: "The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice." in: The Journal of clinical investigation, Vol. 118, Issue 6, pp. 2190-9, (2008) (PubMed).

Target Details for Beclin 1

Target: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Alternative Name: BECN1

Background: Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 (PubMed 19270693)).(supplied by OMIM) . Tissue specificity: Ubiquitous.

Molecular Weight: 60 kDa

Gene ID: 8678

UniProt: Q14457

Pathways: Autophagy