BLK antibody

Catalog No. ABIN968980

This Mouse Monoclonal antibody specifically detects BLK in ELISA and IHC. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for BLK antibody (ABIN968980)

Target: BLK (B Lymphoid Tyrosine Kinase (BLK))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This BLK antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Clone: 9D10D1

Product Details anti-BLK Antibody

Purpose: BLK Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of BLK expressed in E. Coli.

Isotype: IgG2a

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-BLK antibody (ABIN968980)

Tretter, Ross, Dordai, Desiderio: "Mimicry of pre-B cell receptor signaling by activation of the tyrosine kinase Blk." in: The Journal of experimental medicine, Vol. 198, Issue 12, pp. 1863-73, (2003) (PubMed).

Target Details for BLK

Target: BLK (B Lymphoid Tyrosine Kinase (BLK))

Alternative Name: BLK

Background: BLK ( B lymphoid tyrosine kinase), with 505-amino acid protein (about 56KDa), belongs to the Src non-receptor tyrosine kinases family.Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization, and membrane trafficking.Blk is expressed exclusively by B lymphocytes and it is thought to function in a signal transductory pathway specific to this lineage. B lymphoid expression of an active Blk mutant caused proliferation of B progenitor cells and enhanced responsiveness of these cells to interleukin 7. Thus, sustained activation of Blk induces responses normally associated with the pre-BCR.

UniProt: P51451

Pathways: Positive Regulation of Peptide Hormone Secretion, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling