p300 antibody

Catalog No. ABIN969098

The Mouse Monoclonal anti-p300 antibody has been validated for ELISA. It is suitable to detect p300 in samples from Human. There are 2+ publications available.

Quick Overview for p300 antibody (ABIN969098)

Target: p300 (EP300) (E1A Binding Protein P300 (EP300))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This p300 antibody is un-conjugated

Application: ELISA

Clone: 7D8A6

Product Details anti-p300 Antibody

Purpose: EP300 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of EP300 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-p300 antibody (ABIN969098)

Geiger, Sharma, Kim, Nyborg: "The human T-cell leukemia virus type 1 tax protein confers CBP/p300 recruitment and transcriptional activation properties to phosphorylated CREB." in: Molecular and cellular biology, Vol. 28, Issue 4, pp. 1383-92, (2008) (PubMed).

Stauffer, Chang, Huang, Dunn, Thayer: "p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint." in: The Journal of biological chemistry, Vol. 282, Issue 13, pp. 9678-87, (2007) (PubMed).

Target Details for p300

Target: p300 (EP300) (E1A Binding Protein P300 (EP300))

Alternative Name: EP300

Background: EP300: E1A binding protein p300. This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.

UniProt: Q09472

Pathways: p53 Signaling, Notch Signaling, Interferon-gamma Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Regulation of Cell Size