Fibrinogen beta Chain antibody (AA 30-300)

Catalog No. ABIN969136

This Mouse Monoclonal antibody specifically detects Fibrinogen beta Chain in WB and ELISA. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for Fibrinogen beta Chain antibody (AA 30-300) (ABIN969136)

Target: Fibrinogen beta Chain (FGB)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Fibrinogen beta Chain antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 1F9

Product Details anti-Fibrinogen beta Chain Antibody

Binding Specificity: AA 30-300

Purpose: FGB Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human FGB (aa30-300) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Fibrinogen beta Chain antibody (ABIN969136)

Koch, Hoppmann, Biele, Mueller, Schömig, Kastrati: "Fibrinogen genes and myocardial infarction: a haplotype analysis." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 28, Issue 4, pp. 758-63, (2008) (PubMed).

Vu, Bolton-Maggs, Parr, Morris, de Moerloose, Neerman-Arbez: "Congenital afibrinogenemia: identification and expression of a missense mutation in FGB impairing fibrinogen secretion." in: Blood, Vol. 102, Issue 13, pp. 4413-5, (2003) (PubMed).

Target Details for Fibrinogen beta Chain

Target: Fibrinogen beta Chain (FGB)

Alternative Name: FGB

Background: Fibrinogen beta chain, also known as FGB, is a gene found in humans and most other vertebrates with a similar system of blood coagulation.It is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency.

Molecular Weight: 52 kDa

Gene ID: 2244

UniProt: P02675