Fibulin 5 antibody

Catalog No. ABIN969145

This Mouse Monoclonal antibody specifically detects Fibulin 5 in ELISA. It exhibits reactivity toward Human and has been mentioned in 4+ publications.

Quick Overview for Fibulin 5 antibody (ABIN969145)

Target: Fibulin 5 (FBLN5)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Fibulin 5 antibody is un-conjugated

Application: ELISA

Clone: 3F8D5

Product Details anti-Fibulin 5 Antibody

Purpose: Fibulin 5 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of Fibulin 5 expressed in E. Coli.

Isotype: IgM

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Fibulin 5 antibody (ABIN969145)

Wen, Hochholdinger, Sauer, Bruce, Schnable: "The roothairless1 gene of maize encodes a homolog of sec3, which is involved in polar exocytosis." in: Plant physiology, Vol. 138, Issue 3, pp. 1637-43, (2005) (PubMed).

Kadoya, Sasaki, Kostka, Timpl, Matsuzaki, Kumagai, Sakai, Nishiyama, Amano: "Fibulin-5 deposition in human skin: decrease with ageing and ultraviolet B exposure and increase in solar elastosis." in: The British journal of dermatology, Vol. 153, Issue 3, pp. 607-12, (2005) (PubMed).

Wang, LeMaire, Chen, Carter, Shen, Gan, Bartsch, Wilks, Utama, Ou, Thompson, Coselli, Wang: "Decreased expression of fibulin-5 correlates with reduced elastin in thoracic aortic dissection." in: Surgery, Vol. 138, Issue 2, pp. 352-9, (2005) (PubMed).

Lee, Roy, Mogford, Schiemann, Mustoe: "Fibulin-5 promotes wound healing in vivo." in: Journal of the American College of Surgeons, Vol. 199, Issue 3, pp. 403-10, (2004) (PubMed).

Target Details for Fibulin 5

Target: Fibulin 5 (FBLN5)

Alternative Name: Fibulin 5

Background: Fibulin 5(FBLN5), with 448-amino acid protein (about 50 kDa), is a recently discovered multifunctional extracellular matrix protein that mediates endothelial cell adhesion through integrin ligation, regulates cell growth and motility in a context-specific manner, and prevents elastinopathy in vivo. Fibulin-5 is abundantly expressed in great vessels and cardiac valves during embryogenesis, and in many adult tissues including the aorta, lung, uterus and skin, all of which contain abundant elastic fibres. Decreased fibulin-5 may contribute to the pathogenesis of aortic dissection by impairing elastic fiber assembly. Fibulin-5 is also a good marker of skin ageing and that the earlier loss of fibulin-5 may involve age-dependent changes in other elastic fibre components.

UniProt: Q9UBX5

Pathways: SARS-CoV-2 Protein Interactome