FOXD3 antibody

Catalog No. ABIN969152

There is 1 publication for this product available. The Mouse Monoclonal anti-FOXD3 antibody is suitable to detect FOXD3 in samples from Human, Mouse and Monkey. It has been validated for WB and ELISA.

Quick Overview for FOXD3 antibody (ABIN969152)

Target: FOXD3 (Forkhead Box D3 (FOXD3))

Reactivity: Human, Mouse, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This FOXD3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 5G9

Product Details anti-FOXD3 Antibody

Purpose: FOXD3 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human FOXD3 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-FOXD3 antibody (ABIN969152)

Saleem, Banerjee-Basu, Berry, Baxevanis, Walter: "Analyses of the effects that disease-causing missense mutations have on the structure and function of the winged-helix protein FOXC1." in: American journal of human genetics, Vol. 68, Issue 3, pp. 627-41, (2001) (PubMed).

Target Details for FOXD3

Target: FOXD3 (Forkhead Box D3 (FOXD3))

Alternative Name: FOXD3

Background: FoxD3 is a member of the Forkhead Box family and is characterized by a winged-helix DNA-binding structure and the important role it plays in embryonic development . This transcriptional regulator is required for the maintenance of pluripotency in the pre-implantation and peri-implantation stages of mouse embryonic development and is also required for trophoblast formation . FoxD3 is required for the maintenance of the mammalian neural crest, FoxD3(-/-) mouse embryos fail around the time of implantation with loss of neural crest-derived structures . FoxD3 also forms a regulatory network with Oct-4 and NANOG to maintain the pluripotency of ES cells .Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis .Tissue specificity: Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined .

Molecular Weight: 48 kDa

UniProt: Q9UJU5