HDAC4 antibody

Catalog No. ABIN969190

This Mouse Monoclonal antibody specifically detects HDAC4 in WB and ELISA. It exhibits reactivity toward Human and has been mentioned in 3+ publications.

Quick Overview for HDAC4 antibody (ABIN969190)

Target: HDAC4 (Histone Deacetylase 4 (HDAC4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HDAC4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 7B2

Product Details anti-HDAC4 Antibody

Purpose: HDAC4 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human HDAC4 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS containing 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-HDAC4 antibody (ABIN969190)

Shao, Li, Zhang, Liu, Liu, Zhao, Shen, Li: "Involvement of histone deacetylation in MORC2-mediated down-regulation of carbonic anhydrase IX." in: Nucleic acids research, Vol. 38, Issue 9, pp. 2813-24, (2010) (PubMed).

Ficner: "Novel structural insights into class I and II histone deacetylases." in: Current topics in medicinal chemistry, Vol. 9, Issue 3, pp. 235-40, (2009) (PubMed).

Nishino, Miyazaki, Hoshino, Miwa, Horinouchi, Yoshida: "14-3-3 regulates the nuclear import of class IIa histone deacetylases." in: Biochemical and biophysical research communications, Vol. 377, Issue 3, pp. 852-6, (2008) (PubMed).

Target Details for HDAC4

Target: HDAC4 (Histone Deacetylase 4 (HDAC4))

Alternative Name: HDAC4

Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.

Molecular Weight: 119 kDa

Gene ID: 9759

UniProt: P56524

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process