MERTK antibody

Catalog No. ABIN969283

Product Details anti-MERTK Antibody

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MERTK antibody is un-conjugated

Application: ELISA

Purpose: MER Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of MER expressed in E. Coli.

Clone: 7E5G1

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-MERTK antibody (ABIN969283)

McGough, Cummings: "Coeliac disease: a diverse clinical syndrome caused by intolerance of wheat, barley and rye." in: The Proceedings of the Nutrition Society, Vol. 64, Issue 4, pp. 434-50, (2005) (PubMed).

Allouache, Gawande, Tubiana-Hulin, Tubiana-Mathieu, Piperno-Neumann, Mefti, Bozec, Genot: "First-line therapy with gemcitabine and paclitaxel in locally, recurrent or metastatic breast cancer: a phase II study." in: BMC cancer, Vol. 5, pp. 151, (2005) (PubMed).

Seguineau, Soudant, Moal, Delaporte, Miner, Quéré, Samain: "Techniques for delivery of arachidonic acid to Pacific oyster, Crassostrea gigas, spat." in: Lipids, Vol. 40, Issue 9, pp. 931-9, (2005) (PubMed).

Target Details for MERTK

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Alternative Name: MER (MERTK Products)

Background: MER (c-mer proto-oncogene tyrosine kinase) is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. MER has been identified as a tyrosine kinase potentially involved in the development of glioblastomas. It is expressed at highest levels in ovary, prostate, lung and kidney. Gas6, a growth arrest specific gene, and the related anticoagulation factor Protein S have been identified as ligands for the UFO family of receptors. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).

UniProt: Q12866

Pathways: RTK Signaling