MTHFR antibody

Catalog No. ABIN969297

Product Details anti-MTHFR Antibody

Target: MTHFR (Methylenetetrahydrofolate Reductase (NAD(P)H) (MTHFR))

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This MTHFR antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purpose: MTHFR Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human MTHFR expressed in E. Coli.

Clone: 5D3

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-MTHFR antibody (ABIN969297)

Sarecka-Hujar, Zak, Krauze: "Carrier-state of two or three polymorphic variants of MTHFR, IL-6 and ICAM1 genes increases the risk of coronary artery disease." in: Kardiologia polska, Vol. 66, Issue 12, pp. 1269-77, (2009) (PubMed).

Oliveira, Bianco, Bianco, Verreschi, Guedes, Galera, Galera, Barbosa, Lipay: "Prevalence of the polymorphism MTHFR A1298C and not MTHFR C677T is related to chromosomal aneuploidy in Brazilian Turner Syndrome patients." in: Arquivos brasileiros de endocrinologia e metabologia, Vol. 52, Issue 8, pp. 1374-81, (2009) (PubMed).

Target Details for MTHFR

Target: MTHFR (Methylenetetrahydrofolate Reductase (NAD(P)H) (MTHFR))

Alternative Name: MTHFR (MTHFR Products)

Background: The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.

Molecular Weight: 75 kDa

Gene ID: 4524

UniProt: P42898

Pathways: Methionine Biosynthetic Process