PAX6 antibody

Catalog No. ABIN969342

This anti-PAX6 antibody is a Mouse Monoclonal antibody detecting PAX6 in ELISA and FACS. Suitable for Human. This Primary Antibody has been cited in 3+ publications.

Quick Overview for PAX6 antibody (ABIN969342)

Target: PAX6 (Paired Box 6 (PAX6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PAX6 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Clone: 1C8

Product Details anti-PAX6 Antibody

Purpose: PAX6 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human PAX6 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-PAX6 antibody (ABIN969342)

Zhang, Yamada, Fan, Bangaru, Lin, Yang: "The beta subunit of voltage-gated Ca2+ channels interacts with and regulates the activity of a novel isoform of Pax6." in: The Journal of biological chemistry, Vol. 285, Issue 4, pp. 2527-36, (2010) (PubMed).

Hingorani, Williamson, Moore, van Heyningen: "Detailed ophthalmologic evaluation of 43 individuals with PAX6 mutations." in: Investigative ophthalmology & visual science, Vol. 50, Issue 6, pp. 2581-90, (2009) (PubMed).

Mascarenhas, Young, Littlejohn, Yoo, Salgia, Lang: "PAX6 is expressed in pancreatic cancer and actively participates in cancer progression through activation of the MET tyrosine kinase receptor gene." in: The Journal of biological chemistry, Vol. 284, Issue 40, pp. 27524-32, (2009) (PubMed).

Target Details for PAX6

Target: PAX6 (Paired Box 6 (PAX6))

Alternative Name: PAX6

Background: Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells .PAX6 is the most researched of the PAX genes and appears throughout the literature as a "master control" gene for the development of eyes and other sensory organs, certain neural and epidermal tissues as well as other homologous structures, usually derived from ectodermal tissues. This transcription factor is most famous for its use in the interspecifically induced expression of ectopic eyes and is of medical importance because heterozygous mutants produce a wide spectrum of ocular defects such as Aniridia in humans. This gene encodes paired box gene 6, one of many human homologues of the Drosophila melanogaster gene prd. In addition to the hallmark feature of this gene family, a conserved paired box domain, the encoded protein also contains a homeo box domain. Both domains are known to bind DNA, and function as regulators of gene transcription. This gene is expressed in the developing nervous system, and in developing eyes. Mutations in this gene are known to cause aniridia as well as Peter's anomaly, both ocular diseases.

Molecular Weight: 46 kDa

UniProt: P26367

Pathways: Peptide Hormone Metabolism, Carbohydrate Homeostasis