PTH1R antibody

Catalog No. ABIN969372

This anti-PTH1R antibody is a Mouse Monoclonal antibody detecting PTH1R in IHC, ELISA and ICC. Suitable for Human. This Primary Antibody has been cited in 2+ publications.

Quick Overview for PTH1R antibody (ABIN969372)

Target: PTH1R (Parathyroid Hormone 1 Receptor (PTH1R))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PTH1R antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)

Clone: 4D2

Product Details anti-PTH1R Antibody

Purpose: PTH1R Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human PTH1R expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-PTH1R antibody (ABIN969372)

Dean, Vilardaga, Potts, Gardella: "Altered selectivity of parathyroid hormone (PTH) and PTH-related protein (PTHrP) for distinct conformations of the PTH/PTHrP receptor." in: Molecular endocrinology (Baltimore, Md.), Vol. 22, Issue 1, pp. 156-66, (2007) (PubMed).

Yang, Hoang, Kubo, Kawano, Chou, Sowers, Huvos, Meyers, Healey, Gorlick: "Over-expression of parathyroid hormone Type 1 receptor confers an aggressive phenotype in osteosarcoma." in: International journal of cancer. Journal international du cancer, Vol. 121, Issue 5, pp. 943-54, (2007) (PubMed).

Target Details for PTH1R

Target: PTH1R (Parathyroid Hormone 1 Receptor (PTH1R))

Alternative Name: PTH1R

Background: The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene.

Molecular Weight: 66 kDa

Gene ID: 5745

UniProt: Q03431

Pathways: Regulation of Carbohydrate Metabolic Process