STAT6 antibody

Catalog No. ABIN969423

Cited in 3+ publications. The Mouse Monoclonal anti-STAT6 antibody (Clone 7D3) (ABIN969423) specifically detects STAT6 in WB, ELISA and ICC. The antibody is reactive with Human, Mouse, Rat and Monkey samples.

Quick Overview for STAT6 antibody (ABIN969423)

Target: STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))

Reactivity: Human, Mouse, Rat, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This STAT6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Clone: 7D3

Product Details anti-STAT6 Antibody

Purpose: STAT6 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human STAT6 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-STAT6 antibody (ABIN969423)

Ikeuchi, Kobayashi, Arakawa, Suzuki, Tamra, Morikawa: "Polymorphisms in interleukin-4-related genes in patients with minimal change nephrotic syndrome." in: Pediatric nephrology (Berlin, Germany), Vol. 24, Issue 3, pp. 489-95, (2009) (PubMed).

Inomata, Into, Nakashima, Noguchi, Matsushita: "IL-4 alters expression patterns of storage components of vascular endothelial cell-specific granules through STAT6- and SOCS-1-dependent mechanisms." in: Molecular immunology, Vol. 46, Issue 10, pp. 2080-9, (2009) (PubMed).

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, (2009) (PubMed).

Target Details for STAT6

Target: STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))

Alternative Name: STAT6

Background: STAT6 protein is a transcription factor activated by cytokines, particularly interleukin 4 and IL 13. (STAT6-/-) were found to be deficient in IL 4 mediated functions including Th2 helper T cell differentiation, expression of cell surface markers, T cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL 4 mediated proliferation. STAT6 mRNA has been detected in peripheral bloodlymphocytes, colon, intestine, ovary, prostate,thymus, spleen, kidney, liver, lung and placenta. STAT6 is critically involved in Th2 immune response.

Molecular Weight: 94 kDa

Gene ID: 6778

UniProt: P42226

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response