Synaptophysin antibody

Catalog No. ABIN969428

The Mouse Monoclonal anti-Synaptophysin antibody has been validated for WB, IHC and ELISA. It is suitable to detect Synaptophysin in samples from Human and Rat. There are 3+ publications available.

Quick Overview for Synaptophysin antibody (ABIN969428)

Target: Synaptophysin (SYP)

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Synaptophysin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 7H12

Product Details anti-Synaptophysin Antibody

Purpose: SYP Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of SYP expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Synaptophysin antibody (ABIN969428)

Gulubova, Vlaykova: "Chromogranin A-, serotonin-, synaptophysin- and vascular endothelial growth factor-positive endocrine cells and the prognosis of colorectal cancer: an immunohistochemical and ultrastructural study." in: Journal of gastroenterology and hepatology, Vol. 23, Issue 10, pp. 1574-85, (2009) (PubMed).

Sterlacci, Fiegl, Hilbe, Auberger, Mikuz, Tzankov: "Clinical relevance of neuroendocrine differentiation in non-small cell lung cancer assessed by immunohistochemistry: a retrospective study on 405 surgically resected cases." in: Virchows Archiv : an international journal of pathology, Vol. 455, Issue 2, pp. 125-32, (2009) (PubMed).

Xu, Dai, Xiang, Zhao, Ruan, Cheng, Zheng, Shu: "Nutritional factors in relation to endometrial cancer: a report from a population-based case-control study in Shanghai, China." in: International journal of cancer. Journal international du cancer, Vol. 120, Issue 8, pp. 1776-81, (2007) (PubMed).

Target Details for Synaptophysin

Target: Synaptophysin (SYP)

Alternative Name: SYP

Background: Synaptophysin (p38) is an integral membrane protein of small synaptic vesicles in brain and endocrine cells.Synaptophysin contains four transmembrane domains that form a hexameric channel or gap junction-like pore. Synaptophysin binds to the SNARE protein synaptobrevin/VAMP, which prevents the inclusion of synaptobrevin in the synaptic vesicle fusion complex and creates a pool of synaptobrevin for exocytosis when synapse activity increases. Synaptophysin is also responsible for targeting synaptobrevin 2/VAMP2 to synaptic vesicles, a critical component of the fusion complex.

Molecular Weight: 33.8 kDa

Gene ID: 6855

UniProt: P08247

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of long-term Neuronal Synaptic Plasticity