WNT5A antibody

Catalog No. ABIN969460

Product Details anti-WNT5A Antibody

Target: WNT5A (Wingless-Type MMTV Integration Site Family, Member 5A (WNT5A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This WNT5A antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)

Purpose: WNT5A Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of WNT5A expressed in E. Coli.

Clone: 6F2

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-WNT5A antibody (ABIN969460)

Ford, Ekström, Andersson: "Wnt-5a signaling restores tamoxifen sensitivity in estrogen receptor-negative breast cancer cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 10, pp. 3919-24, (2009) (PubMed).

Dai, Hall, Escara-Wilke, Mizokami, Keller, Keller: "Prostate cancer induces bone metastasis through Wnt-induced bone morphogenetic protein-dependent and independent mechanisms." in: Cancer research, Vol. 68, Issue 14, pp. 5785-94, (2008) (PubMed).

Target Details for WNT5A

Target: WNT5A (Wingless-Type MMTV Integration Site Family, Member 5A (WNT5A))

Alternative Name: WNT5A (WNT5A Products)

Background:

Description: WNT5A: wingless-type MMTV integration site family, member 5A. Entrez Protein: NP_003383. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98 % , 98 % and 87 % amino acid identity to the mouse, rat and the xenopus Wnt5A protein, respectively. The experiments performed in Xenopus laevis embryos identified that human frizzled-5 (hFz5) is the receptor for the Wnt5A ligand and the Wnt5A/hFz5 signaling mediates axis induction.

Aliases: hWNT5A

Molecular Weight: 42.3kDa

Gene ID: 7474

HGNC: 7474

UniProt: P41221

Pathways: WNT Signaling, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Cell Size, Tube Formation