SNCG (Breast Cancer-Specific Protein 1) antibody

Catalog No. ABIN969490

Product Details

Target: SNCG (Breast Cancer-Specific Protein 1)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Western Blotting (WB)

Purification: purified

Immunogen: Purified recombinant fragment of SNCG expressed in E. coli.

Clone: 1H10D2

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: 4°C, -20°C for long term storage

References

Surgucheva, McMahon, Surguchov: "gamma-synuclein has a dynamic intracellular localization." in: Cell motility and the cytoskeleton, Vol. 63, Issue 8, pp. 447-58, (2006) (PubMed).

Brown, Lasek: "Polylysine cross-links axoplasmic neurofilaments into tight bundles." in: Cell motility and the cytoskeleton, Vol. 31, Issue 1, pp. 9-21, (1995) (PubMed).

Target Details

Target: SNCG (Breast Cancer-Specific Protein 1)

Background:

Description: SNCG(also designated gamma-synuclein or breast cancer-specific protein 1),with 127-amino acid protein(about 14 kDa), belongs to the synuclein family, which also includes alpha- and beta- synuclein.Three synucleins are located in the neuronal cytosol and enriched in presynaptic terminals,while SNCG is also expressed in many other non-neuronal tissues. SNCG is abnormally expressed in a high percentage of tumor tissues of diversified cancer types, including liver, esophagus, colon, gastric, lung, prostate, cervical, and breast cancer, but rarely expressed in tumor-matched nonneoplastic adjacent tissues. High levels of SNCG have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor development.

Aliases: SR, BCSG1

Gene ID: 6623

HGNC: 6623