Thrombopoietin antibody

Catalog No. ABIN969571

This Mouse Monoclonal antibody specifically detects Thrombopoietin in ELISA and FACS. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for Thrombopoietin antibody (ABIN969571)

Target: Thrombopoietin (THPO)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Thrombopoietin antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Clone: 1B11

Product Details anti-Thrombopoietin Antibody

Purpose: THPO Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human THPO expressed in E. Coli.

Isotype: IgG2a

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Thrombopoietin antibody (ABIN969571)

Graziano, Carone, Panza, Marino, Magini, Romeo, Pession, Seri: "Association of hereditary thrombocythemia and distal limb defects with a thrombopoietin gene mutation." in: Blood, Vol. 114, Issue 8, pp. 1655-7, (2009) (PubMed).

Eissa, Gad, Rabie, El-Gayar: "Thrombopoietin level in patients with chronic liver diseases." in: Annals of hepatology, Vol. 7, Issue 3, pp. 235-44, (2008) (PubMed).

Target Details for Thrombopoietin

Target: Thrombopoietin (THPO)

Alternative Name: THPO

Background: Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Alternate splicing results in multiple transcript variants of this gene.

Molecular Weight: 37.8 kDa

UniProt: P40225

Pathways: JAK-STAT Signaling, Hormone Activity