YAP1 antibody

Catalog No. ABIN969574

This Mouse Monoclonal antibody specifically detects YAP1 in WB, ELISA, IHC and FACS. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for YAP1 antibody (ABIN969574)

Target: YAP1 (Yes-Associated Protein 1 (YAP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This YAP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: 1A12

Product Details anti-YAP1 Antibody

Purpose: YAP1 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human YAP1 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-YAP1 antibody (ABIN969574)

Fernandez-L, Northcott, Dalton, Fraga, Ellison, Angers, Taylor, Kenney: "YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation." in: Genes & development, Vol. 23, Issue 23, pp. 2729-41, (2009) (PubMed).

Zhang, Ji, Yu, Overholtzer, Smolen, Wang, Brugge, Dyson, Haber: "YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway." in: Nature cell biology, Vol. 11, Issue 12, pp. 1444-50, (2009) (PubMed).

Target Details for YAP1

Target: YAP1 (Yes-Associated Protein 1 (YAP1))

Alternative Name: YAP1

Background: This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction.

UniProt: P46937

Pathways: MAPK Signaling, Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha