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anti-Human TNFRSF12A Antibodies:
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Human Monoclonal TNFRSF12A Primary Antibody for Func, IHC (f) - ABIN2749122
Nakayama, Ishidoh, Kojima, Harada, Kominami, Okumura, Yagita: Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death. in Journal of immunology (Baltimore, Md. : 1950) 2002
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Human Monoclonal TNFRSF12A Primary Antibody for Func, IHC (f) - ABIN2749054
Yoriki, Akashi, Sho, Nomi, Yamato, Hotta, Takayama, Matsumoto, Wakatsuki, Migita, Yagita, Nakajima: Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer. in Experimental and therapeutic medicine 2012
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Human Monoclonal TNFRSF12A Primary Antibody for Func, IHC (f) - ABIN2749025
Roos, Wicovsky, Müller, Salzmann, Rosenthal, Kalthoff, Trauzold, Seher, Henkler, Kneitz, Wajant: Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway. in Journal of immunology (Baltimore, Md. : 1950) 2010
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Human Polyclonal TNFRSF12A Primary Antibody for WB - ABIN252585
Chorianopoulos, Heger, Lutz, Frank, Bea, Katus, Frey: FGF-inducible 14-kDa protein (Fn14) is regulated via the RhoA/ROCK kinase pathway in cardiomyocytes and mediates nuclear factor-kappaB activation by TWEAK. in Basic research in cardiology 2010
Human Monoclonal TNFRSF12A Primary Antibody for FACS - ABIN2479572
Girgenrath, Weng, Kostek, Browning, Wang, Brown, Winkles, Michaelson, Allaire, Schneider, Scott, Hsu, Yagita, Flavell, Miller, Burkly, Zheng: TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration. in The EMBO journal 2006
Data suggest that expression of Fn14 on a tumor can initiate cachexia; an antibody against Fn14 may be an effective antineoplastic agent. [REVIEW]
The results suggest that TWEAK (show TNFSF12 Antibodies)/Fn14 interaction directly favors inorganic phosphate-induced vascular smooth muscle cells calcification by activation of both canonical and non-canonical NF-kappaB (show NFKB1 Antibodies) pathways.
TWEAK (show TNFSF12 Antibodies) upregulated the expression of Fn14.
Fn14.TRAIL can be converted into a highly effective TRAIL oligomer upon binding to TWEAK (show TNFSF12 Antibodies) which induces lymphoblast apoptosis.
Data show that aurintricarboxylic acid (ATA) targets the TNF-related WEAK inducer of apoptosis (TWEAK (show TNFSF12 Antibodies))-fibroblast growth factor-inducible 14 (show DDX3X Antibodies) (Fn14) signaling axis, which could potentially be developed as a new therapeutic agent for treatment of glioblastoma (GBM) patients.
TNFRSF12A was knocked down in the SMMC7721 cell line through siRNA. This demonstrated that cells exhibited reduced reproductive and metastatic capacity ex vivo.
In this review article, we summarize studies indicating that (i) Fn14 gene expression is low in normal brain tissue but is upregulated in advanced brain cancers and, in particular, in GB tumors ; TWEAK (show TNFSF12 Antibodies): Fn14 engagement as well as Fn14 overexpression can stimulate glioma cell migration, invasion and resistance to chemotherapeutic agents in vitro.
Fn14 is a receptor of mitogen TWEAK (show TNFSF12 Antibodies) (tumor necrosis factor (show TNF Antibodies)-like weak inducer of apoptosis), expressed on the membranes of HPCs and promoting their proliferation.
EGFR (show EGFR Antibodies) Del 19 may promote Fn14 and JAK1 (show JAK1 Antibodies)/STAT1 (show STAT1 Antibodies) expression in NSCLC.
TWEAK (show TNFSF12 Antibodies)/Fn14 activation induces keratinocyte proliferation under psoriatic inflammation
TWEAK (show TNFSF12 Antibodies)/Fn14 signalling is important in the pathogenesis of ultraviolet B-induced cutaneous disease manifestations in the MRL/lpr (show FAS Antibodies) model of lupus.
Disruption of the TWEAK (show TNFSF12 Antibodies)/Fn14 pathway affects several interconnected pathways, including those associated with IL-13 (show IL13 Antibodies), IL-33 (show IL33 Antibodies), and IL-13Ralpha2, to attenuate 5-fluorouracil-induced intestinal side effects.
TWEAK (show TNFSF12 Antibodies)/Fn14 interactions play an important role in the pathogenesis of neuropsychiatric lupus by increasing the accumulation of inflammatory cells in the choroid plexus, disrupting blood brain barrier integrity, and increasing neuronal damage
TWEAK (show TNFSF12 Antibodies)/Fn14 signaling is strongly implicated in the pathogenesis of the cutaneous manifestations in the MRL/lpr (show FAS Antibodies) model of spontaneous lupus in mice.
In SOD1 (show SOD1 Antibodies) and Neurotomized mice the results of this studysuggest LC3 (show MAP1LC3A Antibodies), Fn14, Bcl3 (show BCL3 Antibodies) and Gadd45a (show GADD45A Antibodies) as candidate genes involved in the maintenance of the severe atrophic state.
Fn14 mediates wound-healing responses that are necessary to survive acute liver injury during alcohol exposure.
Overexpression of Dnmt3a (show DNMT3A Antibodies) inhibits the gene expression of Fn14 and attenuates skeletal muscle atrophy upon denervation. Denervation also causes the activation of ERK1/2 (show MAPK1/3 Antibodies), JNK1 (show MAPK8 Antibodies)/2, and ERK5 (show MAPK7 Antibodies) MAPKs and AP1 (show JUN Antibodies) and SP1 (show SP1 Antibodies).
TWEAK (show TNFSF12 Antibodies)-FN14 signaling is necessary for the healthy adult liver to regenerate normally after acute partial hepatectomy.
The levels of TWEAK receptor Fn14 are increased in skeletal muscle during aging. Deletion of Fn14 attenuates age-associated skeletal muscle fiber atrophy.
this study showed that the apoptosis signal-regulating kinase 1 (ASK1 (show MAP3K5 Antibodies))-JNK1 (show MAPK8 Antibodies)/2 pathway, which was activated by large magnitude mechanical stretch induced expression of Fn14 gene in osteoblasts.
Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
, fibroblast growth factor-inducible immediate-early response protein 14
, tumor necrosis factor receptor superfamily member 12A
, type I transmembrane protein Fn14
, fibroblast growth factor regulated protein 2
, fibroblast growth factor-regulated protein 2
, fibroblast growth factor-inducible 14