This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008].
CTSD
Origin: Human
Host: HEK-293 Cells
Recombinant
The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
AM, ADA, IA, ScA
Redecker, Heckendorf, Grosch, Mersmann, Hasilik: "Molecular organization of the human cathepsin D gene." in: DNA and cell biology, Vol. 10, Issue 6, pp. 423-31, (1991) (PubMed).
Westley, May: "Oestrogen regulates cathepsin D mRNA levels in oestrogen responsive human breast cancer cells." in: Nucleic acids research, Vol. 15, Issue 9, pp. 3773-86, (1987) (PubMed).
Faust, Kornfeld, Chirgwin: "Cloning and sequence analysis of cDNA for human cathepsin D." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 82, Issue 15, pp. 4910-4, (1985) (PubMed).
Aliases for Cathepsin D Proteins
cathepsin D (ctsd) Proteins cathepsin D (LOC398557) Proteins cathepsin D S homeolog (ctsd.S) Proteins cathepsin D (CatD) Proteins lysosomal aspartic protease (LOC5567565) Proteins cathepsin D (LOC100136761) Proteins cathepsin D (CTSD) Proteins cathepsin D (Cathd) Proteins cathepsin D (ctsD) Proteins cathepsin D (catd) Proteins cathepsin D (Ctsd) Proteins cathepsin D-like (LOC443060) Proteins catD Proteins CatD Proteins Cathd Proteins CD Proteins CLN10 Proteins CPSD Proteins CTSD Proteins DDBDRAFT_0205785 Proteins DDBDRAFT_0215012 Proteins DDB_0205785 Proteins DDB_0215012 Proteins DKFZp469J0315 Proteins fb93e11 Proteins fj17b09 Proteins LOC398557 Proteins LOC100136761 Proteins wu:fb93e11 Proteins wu:fj17b09 Proteins