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the association between particular MC1R alleles and the risk of skin cancers, was investigated.
there is an association between TERT (show TERT Proteins) promoter mutations and MC1R variants in melanoma patients
with regard to cutaneous malignant melanoma risk, no association found in the combination of GSTP1 Ile105Val with MC1R RHC-variant alleles [meta-analysis]
In familial melanoma patients, the presence of MC1R R variants was associated with an increased prevalence of environmental risk factors and features associated with UV radiation-induced damage.
These data clearly show a new and hitherto unsuspected role for MC1R in noncutaneous solid tissues before birth.
In both melanoma cell lines, alphaMSH (show POMC Proteins) determined the reduction of proliferation through the PI(4,5)P2/PLC (show HSPG2 Proteins) pathway, employing PPARgamma (show PPARG Proteins) as an effector element. These evidence could offer perspectives for new therapeutic approaches for melanoma.
Carriage of any MC1R variant, one variant and two or more variants, compared with not having such variants was significantly associated with fair hair color, skin type I/II, and presence of freckles.
key molecular events driving MC1R-mediated enhancement of genome maintenance and MC1R-induced pigment induction in melanocytes are distinct
amino acid residue 128 in Transmembrane 3 (TM3 (show TPM1 Proteins)) of MC1R, or amino acid residue L133 in TM3 (show TPM1 Proteins) of the MC4R (show MC4R Proteins), play crucial roles in ligand des (show DES Proteins)-Trp (show TBPL1 Proteins)(9)-NDP (show NDP Proteins)-alpha-MSH selectivity at MC1R or MC4R (show MC4R Proteins).
In a heterologous expression system, MC1R-dependent Arrestins B ubiquitination was enhanced by overexpression of MGRN1 (show MGRN1 Proteins) and was impaired by siRNA-mediated MGRN1 (show MGRN1 Proteins) knockdown thus pointing to MGRN1 (show MGRN1 Proteins) as the responsible E3-ligase.
Collectively, our findings suggest that melanocortin therapy confers a proteinuria reducing and podoprotective effect in proteinuric glomerulopathies via MC1R-independent mechanisms.
results highlight a central role for MC1R palmitoylation in pigmentation and protection against melanoma
We conclude that MC1R plays an important role in regulating melanoma growth and morphology
Activation of Mc1r prevents cholesterol uptake and confers protection against macrophage foam cell formation.
MC1-mediated effects were reduced, and MC3 (show MC3R Proteins) anti-inflammatory circuits predominated. Mice bearing a nonfunctional MC1 displayed a transient exacerbation of neutrophil recruitment after global I/R, which diminished by 2 hours.
A melanin-independent interaction between Mc1r and Met signaling pathways is required for hepatocyte growth factor (show HGF Proteins)-dependent melanoma.
In summary, we have identified a new alpha-MSH-MC1R physiologic pathway that reduces HO-induced RPE (show RPE Proteins) cell damage, and might minimize the risk of developing AMD (show AMD1 Proteins).
Absence of Mc1r does not impair the inflammatory response to UV radiation or the generation of immunosuppression.
MC1R decrease the inflammation in vitro and vivo, and might be part of a signaling pathway in inflammatory diseases.
Evolution of mc1r in zebrafish is reported.
This study demonstrated a direct role for mc1r in zebrafish melanosome dispersal in response to background, and used chemical modification of this pathway to uncover a possible new layer of regulation in melanosome dispersal in zebrafish.
Considering that mRNA for MC2R and the MC1R variants are present in head kidney cells, the authors hypothesized that MC2R activity is modulated in part by different binding affinities of the MC1R variants for MRAP.
no significant relationship with behavior at the MC1R locus
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.
, melanocyte-stimulating hormone receptor
, melanotropin receptor
, extension recessive yellow
, melanocortin receptor 1
, melanocortin-1 receptor
, tobacco darkening
, melanocortin 1 receptor
, Melanotropin receptor
, Melanocortin receptor 1
, Melanocyte-stimulating hormone receptor
, alpha melanocyte stimulating hormone receptor
, tubulin, beta 3 class III