Browse our MC1 Receptor Proteins (MC1R)

Human Melanocortin 1 Receptor (MC1R) interaction partners

1. the association between particular MC1R alleles and the risk of skin cancers, was investigated.

2. there is an association between TERT (show TERT Proteins) promoter mutations and MC1R variants in melanoma patients

3. with regard to cutaneous malignant melanoma risk, no association found in the combination of GSTP1 Ile105Val with MC1R RHC-variant alleles [meta-analysis]

4. In familial melanoma patients, the presence of MC1R R variants was associated with an increased prevalence of environmental risk factors and features associated with UV radiation-induced damage.

5. These data clearly show a new and hitherto unsuspected role for MC1R in noncutaneous solid tissues before birth.

6. In both melanoma cell lines, alphaMSH (show POMC Proteins) determined the reduction of proliferation through the PI(4,5)P2/PLC (show HSPG2 Proteins) pathway, employing PPARgamma (show PPARG Proteins) as an effector element. These evidence could offer perspectives for new therapeutic approaches for melanoma.

7. Carriage of any MC1R variant, one variant and two or more variants, compared with not having such variants was significantly associated with fair hair color, skin type I/II, and presence of freckles.

8. key molecular events driving MC1R-mediated enhancement of genome maintenance and MC1R-induced pigment induction in melanocytes are distinct

9. amino acid residue 128 in Transmembrane 3 (TM3 (show TPM1 Proteins)) of MC1R, or amino acid residue L133 in TM3 (show TPM1 Proteins) of the MC4R (show MC4R Proteins), play crucial roles in ligand des (show DES Proteins)-Trp (show TBPL1 Proteins)(9)-NDP (show NDP Proteins)-alpha-MSH selectivity at MC1R or MC4R (show MC4R Proteins).

10. In a heterologous expression system, MC1R-dependent Arrestins B ubiquitination was enhanced by overexpression of MGRN1 (show MGRN1 Proteins) and was impaired by siRNA-mediated MGRN1 (show MGRN1 Proteins) knockdown thus pointing to MGRN1 (show MGRN1 Proteins) as the responsible E3-ligase.

Mouse (Murine) Melanocortin 1 Receptor (MC1R) interaction partners

1. These data clearly show a new and hitherto unsuspected role for MC1R in noncutaneous solid tissues before birth.

2. Collectively, our findings suggest that melanocortin therapy confers a proteinuria reducing and podoprotective effect in proteinuric glomerulopathies via MC1R-independent mechanisms.

3. results highlight a central role for MC1R palmitoylation in pigmentation and protection against melanoma

4. We conclude that MC1R plays an important role in regulating melanoma growth and morphology

5. Activation of Mc1r prevents cholesterol uptake and confers protection against macrophage foam cell formation.

6. MC1-mediated effects were reduced, and MC3 (show MC3R Proteins) anti-inflammatory circuits predominated. Mice bearing a nonfunctional MC1 displayed a transient exacerbation of neutrophil recruitment after global I/R, which diminished by 2 hours.

7. A melanin-independent interaction between Mc1r and Met signaling pathways is required for hepatocyte growth factor (show HGF Proteins)-dependent melanoma.

8. In summary, we have identified a new alpha-MSH-MC1R physiologic pathway that reduces HO-induced RPE (show RPE Proteins) cell damage, and might minimize the risk of developing AMD (show AMD1 Proteins).

9. Absence of Mc1r does not impair the inflammatory response to UV radiation or the generation of immunosuppression.

10. MC1R decrease the inflammation in vitro and vivo, and might be part of a signaling pathway in inflammatory diseases.

Zebrafish Melanocortin 1 Receptor (MC1R) interaction partners

1. Evolution of mc1r in zebrafish is reported.

2. This study demonstrated a direct role for mc1r in zebrafish melanosome dispersal in response to background, and used chemical modification of this pathway to uncover a possible new layer of regulation in melanosome dispersal in zebrafish.

Rainbow Trout (Oncorhynchus mykiss) Melanocortin 1 Receptor (MC1R) interaction partners

1. Considering that mRNA for MC2R and the MC1R variants are present in head kidney cells, the authors hypothesized that MC2R activity is modulated in part by different binding affinities of the MC1R variants for MRAP.

Horse (Equine) Melanocortin 1 Receptor (MC1R) interaction partners

1. no significant relationship with behavior at the MC1R locus