Browse our anti-HIPK2 (HIPK2) Antibodies

Zebrafish Homeodomain Interacting Protein Kinase 2 (HIPK2) interaction partners

1. Hipk2 promotes PP1c-mediated Dvl (show DVL2 Antibodies) dephosphorylation via its C-terminal domain and is essential Dvl (show DVL2 Antibodies) stability.

Human Homeodomain Interacting Protein Kinase 2 (HIPK2) interaction partners

1. Immunoprecipitation and pulldown experiments identified DCAF7 (show DCAF7 Antibodies) as an adaptor for the association of the adenovirus E1A (show BCKDHA Antibodies) protein with DYRK1A (show DYRK1A Antibodies) and HIPK2

2. HIPK2 polymorphisms rs2058265, rs6464214, and rs7456421 may have a role in kidney stone disease in Chinese males

3. HIPK2 overexpression may be a potential prognostic marker for predicting prognoses and a high risk of recurrence, particularly in patients with HPV-positive Tonsillar squamous cell carcinomas.

4. Furthermore, our results suggest that modulation of either HIPK2 levels or activity could be exploited to impair NRF2 (show GABPA Antibodies)-mediated signalling in cancer cells, and thus sensitise them to chemotherapeutic drugs.

5. PARP1 (show PARP1 Antibodies) can modulate the tumor-suppressing function of HIPK2 by regulating the protein stability of HIPK2.

6. Data show that HIPK2-T566 phosphorylation contributes to UV-induced HIPK2 activity but it is dispensable for doxorubicin response.

7. In this study, we report that the kinase HIPK2 is responsible for facilitating the Fbw7 (show FBXW7 Antibodies)-dependent proteasomal degradation of Notch1 (show NOTCH1 Antibodies) by phosphorylating its intracellular domain (Notch1 (show NOTCH1 Antibodies)-IC) within the Cdc4 (show FBXW7 Antibodies) phosphodegron motif.

8. the migration and invasion of hepatocellular carcinoma cells were impaired by knockdown of histone deacetylase 5 (show HDAC5 Antibodies) or hypoxia-inducible factor-1alpha but rescued when eliminating homeodomain-interacting protein kinase-2 in hepatocellular carcinoma cells, which suggested the critical role of histone deacetylase 5 (show HDAC5 Antibodies)-homeodomain-interacting protein kinase-2-hypoxia-inducible factor-1alpha pathway in hypoxia-induced metastasis.

9. These results suggest that the HIPK2-phospho-Ser271 CREB (show CREB1 Antibodies) axis is a new arsenic-responsive CREB (show CREB1 Antibodies) activation mechanism in parallel with the PKA-phospho-Ser133 CREB (show CREB1 Antibodies) axis.

10. Results demonstrated that HIPK2 may function as a novel regulator to modulate hepatic stellate cells activation, potentially by inhibiting the TGF-beta1 (show TGFB1 Antibodies)/Smad3 (show SMAD3 Antibodies) signaling pathway.

Mouse (Murine) Homeodomain Interacting Protein Kinase 2 (HIPK2) interaction partners

1. Protein levels of HIPK2 were increased in high glucose or TGF-beta (show TGFB1 Antibodies)-treated mouse glomerular mesangial cells. The HG- or TGF-beta (show TGFB1 Antibodies)-induced upregulation of p-MeCP2, NOX4 (show NOX4 Antibodies) and primary miR (show MLXIP Antibodies)-25, but downregulation of precursor and mature miR (show MLXIP Antibodies)-25, were attenuated by Hipk2 siRNA. The SIAH1 (show SIAH1 Antibodies)/HIPK2/MeCP2 axis played a novel role for in suppressing miR (show MLXIP Antibodies)-25 processing and thereby upregulating NOX4 (show NOX4 Antibodies) in early diabetic nephropathy.

2. Data show that HIPK2-T566 phosphorylation contributes to UV-induced HIPK2 activity but it is dispensable for doxorubicin response.

3. reveal a previously unrecognized role of HIPK2 activation in ER-stress-mediated neurodegeneration and its potential role as a biomarker and therapeutic target for amyotrophic lateral sclerosis

4. Results indicate that Hipk2 exerts a relevant role in the survival of cerebellar Purkinje cells and that Hipk2 genetic ablation generates cerebellar dysfunction compatible with an ataxic-like phenotype.

5. HIPK2 is ubiquitinated upon heat shock.

6. Phosphorylation of KLF3 (show KLF3 Antibodies) and CtBP2 (show CTBP2 Antibodies) by HIPK2 strengthens the interaction between these two factors and increases transcriptional repression by KLF3 (show KLF3 Antibodies).

7. Homeodomain-interacting protein kinase 2, a novel autoimmune regulator (show AIRE Antibodies) interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells.

8. Hipk2 has an essential role in mouse white fat development

9. data identify Hipk2 as a novel regulator of C/EBPbeta (show CEBPB Antibodies) and implicate different protein kinases in the cooperation of p300 (show NOTCH1 Antibodies) with C/EBPbeta (show CEBPB Antibodies) and C/EBPalpha (show CEBPA Antibodies)

10. Data indicate a critical kinase HIPK2 function in cytokinesis and in the prevention of tetraploidization.