Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species and application
anti-Human SMAD4 Antibodies:
anti-Mouse (Murine) SMAD4 Antibodies:
anti-Rat (Rattus) SMAD4 Antibodies:
Go to our pre-filtered search.
Human Polyclonal SMAD4 Primary Antibody for IF, IHC (p) - ABIN272224
Izumi, Nakamura, Tokumo, Mano: A minute pancreatic ductal adenocarcinoma with lipomatous pseudohypertrophy of the pancreas. in JOP : Journal of the pancreas 2011
Show all 5 Pubmed References
Human Monoclonal SMAD4 Primary Antibody for FACS, IF - ABIN967047
Smolander, Vogt, Maillard, Zweiacker, Littke, Hengelage, Burnier: Dose-dependent acute and sustained renal effects of the endothelin receptor antagonist avosentan in healthy subjects. in Clinical pharmacology and therapeutics 2009
Show all 3 Pubmed References
Human Polyclonal SMAD4 Primary Antibody for IHC (p), WB - ABIN3044024
Tang, Li, Yu, Gao, Liu, Chen, Xing, Liu, Yao: Quercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6/SMAD4 signaling pathway. in The Journal of nutritional biochemistry 2014
Show all 2 Pubmed References
Human Monoclonal SMAD4 Primary Antibody for ICC, WB - ABIN3043668
Chen, Kong, Wan, Xiao, Li, Wang, Lin, Wang: Effects of huogu I formula (I) on correlated factors of bone regeneration in chickens with steroid-induced necrosis of femoral head. in Chinese journal of integrative medicine 2012
Show all 2 Pubmed References
Human Monoclonal SMAD4 Primary Antibody for ICC, FACS - ABIN969403
Yao, Yin, Lian, Tian, Liu, Li, Sun: MicroRNA-224 is involved in transforming growth factor-beta-mediated mouse granulosa cell proliferation and granulosa cell function by targeting Smad4. in Molecular endocrinology (Baltimore, Md.) 2010
Show all 2 Pubmed References
Human Polyclonal SMAD4 Primary Antibody for IF, WB - ABIN392165
Lessard, Rivas, Alves-Wagner, Hirshman, Gallagher, Constantin-Teodosiu, Atkins, Greenhaff, Qi, Gustafsson, Fielding, Timmons, Britton, Koch, Goodyear: Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks. in Diabetes 2013
Human Monoclonal SMAD4 Primary Antibody for FACS - ABIN4895797
Geng, Chen, Yuan, Peng, Maitra, Diao, Chen, Zhang, Hu, Qi, Pierce, Ling, Xiong, Li: The persistence of low-grade inflammatory monocytes contributes to aggravated atherosclerosis. in Nature communications 2016
Human Polyclonal SMAD4 Primary Antibody for WB - ABIN4354704
Kidd, Modlin, Pfragner, Eick, Champaneria, Chan, Camp, Mane: Small bowel carcinoid (enterochromaffin cell) neoplasia exhibits transforming growth factor-beta1-mediated regulatory abnormalities including up-regulation of C-Myc and MTA1. in Cancer 2007
LPS (show IRF6 Antibodies) mediates intercellular tight junction destruction among TECs and RhoT1 (show RHOT1 Antibodies)/SMAD-4/JAM-3 (show JAM3 Antibodies) is a pivotal pathway to mediate the phenomenon.
the results indicated that miR3147 may serve an oncogenic role in vulvar squamous cell carcinoma (VSCC) by targeting Smad4. miR3147 may represent a novel potential therapeutic target marker for VSCC.
Data indicate that in pancreatic cancer cells, the expression of ENG (show ENG Antibodies) may be controlled by a pathway mediated by SMAD4.
Data indicate that absence of KRAS, TP53 (show TP53 Antibodies) and SMAD4 genetic alterations may identify a subset of pancreatic carcinomas with better outcome.
Results demonstrated that SMAD4 is the direct target of miR (show MLXIP Antibodies)-19b-3p in colon cancer. Its expression is downregulated in colon cancer contributing to oxaliplatin resistance.
We found expression of pSmad2/3 and Smad4 in different liver tissues, with up-regulated expression of both antibodies in chronic hepatitis C with higher stage of fibrosis and higher grade of activity. Smad4 expression up-regulated in hepatocellular carcinoma compared to chronic hepatitis C lesions, so it could identify patients with high risk for hepatocellular carcinoma.
SMAD4 mutation is independently associated with worse outcomes among patients undergoing resection of colorectal liver metastases.
Our study demonstrates that loss of SMAD4 expression is a signature characterizing the cetuximab-resistant phenotype and suggests that SMAD4 expression may be a determinant of sensitivity/resistance to EGFR (show EGFR Antibodies)/MAPK (show MAPK1 Antibodies) or EGFR (show EGFR Antibodies)/JNK (show MAPK8 Antibodies) inhibition in HPV-negative head and neck squamous cell carcinoma tumors
Whole-genome sequencing and confirmatory Sanger sequencing of junction PCR products were used to show that in each of the 5 cases, the SMAD4 processed gene was integrated at the same position on chromosome 9, located within the last intron of the SCAI (show SCAI Antibodies) gene
SMAD4 which can form a SMAD3 (show SMAD3 Antibodies)/SMAD4 complex induced by TGFbeta (show TGFB1 Antibodies).
Loss of Smad4 in neural progenitor cells impairs adult neurogenesis in the subventricular zone.
Reduced bone-mass and accelerated osteoclastogenesis seen in Smad4-cKO were abrogated by Prdm1 (show PRDM1 Antibodies) deletion. Administration of latent-TGFbeta1 (show TGFB1 Antibodies)-Fc to wild-type mice antagonized LPS (show TLR4 Antibodies)-induced bone destruction in a model of activated osteoclast-mediated bone destruction
miR146b5p directly targeted Smad4 and negatively regulated the transforming growth factor (TGF)-beta (show TGFB1 Antibodies) signaling pathway, which contributed to the neural commitment of Pluripotent stem cells (PSCs). Collectively, our findings uncover the essential role of miR146b5p in the neural conversion of PSCs.
study reveals a critical mechanism by which TGFbeta (show TGFB1 Antibodies) controls TH17 cell differentiation and uncovers the SKI (show SKI Antibodies)-SMAD4 axis as a potential therapeutic target for treating TH17-related diseases
The binding motif of miR26b5p in the Smad4 3'UTR (show UTS2R Antibodies) was identified as UACUUGA at position 978-984.
Smad4 expression in T lymphocytes plays a protective role in the development of autoimmune Sjogren's syndrome in the nonobese diabetic mouse.
SMAD4 defect causes auditory neuropathy via specialized disruption of cochlear ribbon synapses.
germ-cell-knockout mice were fertile and did not exhibit any detectable abnormalities in spermatogenesis, indicating that Smad4 is not required for the production of sperm; instead, these data indicate a cell type-specific requirement of Smad4 primarily during testis development.
Smad4 deletion in T cells of NOD mice accelerated the development of autoimmune diabetes.
Smad4 regulates osteoblast apoptosis and mineralization in vitro.
Activated TGF-beta (show TGFB1 Antibodies) signaling rescued miR (show MYLIP Antibodies)-143-reduced FSHR (show FSHR Antibodies) and intracellular signaling molecules, and miR (show MYLIP Antibodies)-143-induced porcine granulosa cell apoptosis.
miR26b may have a proapoptotic role in granulosa cells by regulating SMAD4 expression.
These observations establish an important role of SMAD4 in the regulation of the response of porcine granulosa cells to FSH (show BRD2 Antibodies).
Data suggest SMAD4 mRNA is increased in oocytes during maturation, is maximal in 2-cell blastocysts, remains elevated through 8-cell stage, and is decreased in remaining ectogenesis; embryotrophic actions of follistatin (show FST Antibodies) are SMAD4 dependent.
ALK5 (show TGFBR1 Antibodies) and Smad4 have roles in TGF-beta1 (show TGFB1 Antibodies)-induced pulmonary endothelial permeability
miR (show MYLIP Antibodies)-183 positively regulates hircine preadipocyte differentiation by inhibiting expression of Smad4.
TGF-beta (show TGFB1 Antibodies) signaling has a role in nuclear localization of transcription factor Smad4
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
Mothers against decapentaplegic-like protein 4
, mothers against decapentaplegic homolog 4
, Smad4 protein
, SMAD family member 4
, mothers against decapentaplegic homolog 4-like
, MAD homolog 4
, SMAD, mothers against DPP homolog 4
, deleted in pancreatic carcinoma locus 4
, deletion target in pancreatic carcinoma 4
, mothers against decapentaplegic, Drosophila, homolog of, 4
, Smad 4
, deletion target in pancreatic carcinoma 4 homolog
, mothers against DPP homolog 4
, MAD (mothers against decapentaplegic Drosophila) homolog 4
, SMAD 4
, MAD, mothers against decapentaplegic homolog 4
, mothers against DPP-like 4
, mothers against decapentaplegic-like 4