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Human IL 18 Protein expressed in Escherichia coli (E. coli) - ABIN413464
Kahlenberg, Thacker, Berthier, Cohen, Kretzler, Kaplan: Inflammasome activation of IL-18 results in endothelial progenitor cell dysfunction in systemic lupus erythematosus. in Journal of immunology (Baltimore, Md. : 1950) 2011
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MyD88 (show MYD88 Proteins) signaling in myeloid and dendritic cells is dispensable for IFN-gamma (show IFNG Proteins)-dependent control of type A F. tularensis infection.
study found that IL-18 and IL-1beta (show IL1B Proteins) are differentially regulated. Despite being constitutively expressed, IL-18 expression was increased and sustained after stimulation of TLRs. In contrast, IL-1beta (show IL1B Proteins) was induced but not sustained after chronic treatment.
the GLA (show GLA Proteins)-SE adjuvant operates through interaction with IL-18-producing SCMsmall ef, Cyrillic for the rapid induction of B cell expansion and differentiation, Ab secretion, and Th1 (show HAND1 Proteins) responses
IL-18 is essentially involved in mediating C. jejuni infection in the gnotobiotic mouse model.
These results demonstrate a central role for the AIM2 (show AIM2 Proteins) inflammasome in preventing dysbiosis and intestinal inflammation through regulation of the IL-18/IL-22BP (show IL22RA2 Proteins)/IL-22 (show IL22 Proteins) and STAT3 (show STAT3 Proteins) pathway
Aldosterone induced IL-18 gene expression in renal tubular epithelial cells in a concentration- and time-dependent manner.
this study demonstrated the critical function of IL-18 in lipid metabolism and these findings might contribute to the progress of novel treatments for nonalcoholic fatty liver disease or nonalcoholic steatohepatitis.
Results indicated that IL-18 has roles apart from those as a proinflammatory cytokine in cardiac myocytes and suggested that IL-18 contributes to the homeostatic maintenance of mitochondrial function and gap-junction turnover in cardiac myocytes, possibly by upregulating autophagy.
IL-18-elicited NK cell perforin (show PRF1 Proteins) responses seem to be critical for coordinating mucosal inflammation during early infection
Data indicate that NLRC4 (show NLRC4 Proteins) activation in Intestinal epithelial cells (IECs) leads to cell expulsion and IL-18 release, and implicate Caspase-8 (show CASP8 Proteins) in NLRC4 (show NLRC4 Proteins) inflammasome responses in vivo by generation of doubly deficient in Caspase-1 (show CASP1 Proteins) and Caspase-8 (show CASP8 Proteins).
Study reports that the monocyte-derived cytokines IL-12 (show IL12A Proteins) and IL-18 act synergistically on porcine gammadelta T cells to induce IFN-gamma (show IFNG Proteins) production. Additional stimuli such as the mitogen ConA and IL-2 (show IL2 Proteins) are necessary to activate the cells for enhanced proliferation.
IL-18 concentration in saliva (show RAG1AP1 Proteins) was significantly increased during a 60-min acute immobilization stress in thirteen 5-month-old pigs. These results are the first evidence of a stress-related change of IL-18 in pig saliva (show RAG1AP1 Proteins).
endometrial expression of CASP1 (show CASP1 Proteins) and IL18 associated with pregnancy establishment; alteration of CASP1 (show CASP1 Proteins) and IL18 following premature exposure of uterus to estrogen during early pregnancy may contribute to conceptus loss between Days 15 to 18 of pregnancy
Porcine IL-18 regulates anti-pig cellular rejection in C57BL/6 mice.
The development of urticaria, asthma, dermatitis, rhinitis, and eosinophilic disorders all have demonstrated correlations to increased IL-18 levels either in the tissue or systemically. IL-18 represents a novel site of immune regulation in not only allergic conditions, but also autoimmune diseases and other instances of aberrant immune functioning.
tuberculous lymphadenitis (TBL) is therefore, characterized by reduced systemic and antigen-specific concentrations of IL-1beta (show IL1B Proteins) and IL-18, which are reversible following anti-TB treatment, indicating that these cytokines are potential correlates of protective immunity in TBL.
Results suggest that a common functional IL18 haplotype associated with heightened proinflammatory responses confers susceptibility to stress-related depression and anxiety through effects on threat-related amygdala function, a risk pathway specific to women.
human platelets contain transcripts for the IL-18 gene. They synthesize the cytokine de novo, process and release it upon activation.
abnormal IL-18 expression is induced by genital infection and induces damage to male reproductive capacity, thereby causing male infertility
IL-18 level was found to be significantly elevated in CAD patients compared with control individuals
The serum levels of IL-37, which were correlated with antibody production and the serum levels of total IL-18 and IL-18BP (show IL18BP Proteins), were elevated in the patients with primary Sjogren's syndrome.
an imbalance in the production of IL-18 and its antagonist (an increase in the production of IL-18 with a decrease, no increase or an insufficient increase in the production of IL-18BP (show IL18BP Proteins)) has been described in many chronic inflammatory diseases in humans.
among systemic sclerosis patients in China, dyspnea was significantly associated with IL-18 -607C/A genotype frequency
sickle red blood cell induced TLR9 (show TLR9 Proteins), NLRP3 (show NLRP3 Proteins), Caspase-1 (show CASP1 Proteins), IL-1beta (show IL1B Proteins) and IL-18 expression and induced IL-1beta (show IL1B Proteins), LTB4 (show PTGR1 Proteins) and nitrite production in PBMC cultures.
These results suggest that BAPC-1 is a stem/progenitor cell line and modulates the immuno-endocrine function of the anterior pituitary cells through its production of interleukin-18 and the IL-18 receptor.
Pressure overload, while enhancing IL-18 and IL-18R expression in hypertrophied and failing hearts, markedly attenuated the level of expression of the endogenous IL-18 antagonist IL-18BP (show IL18BP Proteins).
The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, IL-1 gamma
, interferon gamma-inducing factor
, interferon-gamma-inducing factor
, interleukin-1 gamma
, interferon gamma inducing factor
, Interferon gamma-inducing factor
, interleukin 18
, uncharacterized protein LOC100734451