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A novel frameshift mutation c.254_255delGA (p.Arg85Asnfs*6) in the MBD5 gene was identified in a family with intellectual disability and epilepsy.
Circadian rhythm gene expression altered by haploinsufficiency of MBD5.
Results show that when MBD5 and RAI1 (show DOM3Z Proteins) are haploinsufficient, they perturb several common pathways that are linked to neuronal and behavioral development.
Reduced MBD5 dosage leads to mRNA and microRNA expression patterns and DNA methylation (show HELLS Proteins) patterns more characteristic of differentiating than proliferating neural stem cells. This balance change may underlie neurodevelopmental disorders.
We studied and showed that both MBD5 and MBD6 interact with the mammalian PR-DUB Polycomb protein complex in a mutually exclusive manner, and that the MBD of MBD5 and MBD6 is both necessary and sufficient to mediate this interaction.
The features associated with a deletion, mutation or duplication of MBD5 and the gene expression changes observed support MBD5 as a dosage-sensitive gene critical for normal development.
study demonstrates that haploinsufficiency of MBD5 causes diverse phenotypes, yields insight into the spectrum of resulting neurodevelopmental and behavioral psychopathology and provides clinical context for interpretation of MBD5 structural variations.
A genomic copy number variant analysis implicates the MBD5 and HNRNPU (show HNRNPU Proteins) genes in Chinese children with infantile spasms and expands the clinical spectrum of 2q23.1 deletion.
Identified de novo intragenic deletions of MBD5 in three patients.
MBD5 was tied to neurodevelopmental disorders following the identification of microdeletions on chromosome 2q22-2q23.
This study indicates that the Mbd5(+/) (GT) mouse model recapitulates most of the hallmark phenotypes observed in 2q23.1 deletion carriers including abnormal social behavior, cognitive impairment, and motor and craniofacial abnormalities.
MBD5 regulates iron metabolism via methylation-independent genomic targeting of Fth1 (show FTH1 Proteins).
These results indicate Mbd5 as an essential factor for mouse postnatal growth and maintenance of glucose homeostasis
This gene encodes a member of the methyl-CpG-binding domain (MBD) family. The MBD consists of about 70 residues and is the minimal region required for a methyl-CpG-binding protein binding specifically to methylated DNA. In addition to the MBD domain, this protein contains a PWWP domain (Pro-Trp-Trp-Pro motif), which consists of 100-150 amino acids and is found in numerous proteins that are involved in cell division, growth and differentiation. Mutations in this gene cause mental retardation autosomal dominant type 1. Haploinsufficiency of this gene is associated with a syndrome involving microcephaly, intellectual disabilities, severe speech impairment, and seizures. Alternatively spliced transcript variants have been found, but their full-length nature is not determined.
methyl-CpG binding domain protein 5
, methyl-CpG-binding domain protein 5
, methyl-CpG-binding domain protein 5-like
, methyl-CpG-binding protein MBD5